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R&D Trends: Depression - Clinical attrition driven by mature market conditions

y standardized to a duration of just 8 weeks

Comparator trials can provide a compelling argument for using one drug ahead of another

Future developments in clinical trial design

Treatment-resistant depression clinical trial design

Adjunctive therapy clinical trial design


Glutamate receptor modulation

NMDA receptor antagonists and partial agonists

Metabotropic glutamate receptor antagonists

Targeting neuropeptides for depression


Vasopressin receptor antagonists

Neurokinin receptor antagonists


Specific targeting of treatment-resistant patients

A label for treatment-resistant depression will bypass competition with generic first-line antidepressants

Treatment-resistant depression is characterized by a large target population and substantial unmet need

Biomarkers for depression

Considerable variations in treatment outcomes exist

Biomarkers may have utility in identifying likely responders and improving treatment outcomes

The commercial appeal of reduced R&D spend and a competitive advantage is a bonus

Biomarkers in clinical development


Journal papers


Datamonitor reports


Contributing experts

Conferences attended

Report methodology



Table: Products in clinical development for depression, January 2012

Table: Depression clinical pipeline, by mode of action and development stage, January 2012

Table: Discontinued pipeline drugs in depression, 2010–12

Table: Discontinued drugs formerly in development for depression, by mode of action and developmental stage, 2010–12

Table: Lexapro (escitalopram; Forest/Lundbeck) – drug profile in depression, 2012

Table: Defining the go

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