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R&D Trends: Depression - Clinical attrition driven by mature market conditions

opular approaches include glutamate and neuropeptide receptor modulation. Datamonitor sees the future of treatment in depression as the specific targeting of treatment-resistant patients.Clinical trial design in depression is largely standardized. Although not required, head-to-head trials may allow for a more favorable label and explicit marketing claims. Datamonitor believes that future trials will be designed for regulatory approval in patients with treatment-resistant depression, or for use as an add-on to existing therapies.What are the key trends in the depression pipeline?What is the clinical gold standard and how do new candidates have to compare to this to successfully penetrate the market?How will new antidepressant treatments evolve in the next 20 years?








Strategic scoping and focus

Update details: January 2012

Datamonitor key findings

Related reports


Overview of the depression pipeline

Datamonitor has identified 46 separate programs in clinical development

Emerging features of the depression pipeline

Changes in pipeline dynamics

Companies involved in the depression pipeline

Discontinued pipeline drugs in depression

54 distinct depression projects have been discontinued since 2010

The vast majority of discontinuations happen either during preclinical testing or Phase II studies

Neuropeptide modulators and monoamine reuptake inhibitors head the list of discontinued projects


Comparator therapies

Lexapro (escitalopram; Forest/Lundbeck)

Target product profile versus current level of attainment


Clinical trials

Commonly used clinical trial endpoints for depression

Typical trial design

Trial length is commonl

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