Quigley Announces Successful Poultry Study of Chickens With Infectious Bronchitis; Plans to Approach the Poultry Industry for Potential Commerc...(o offer the poultry industry a natural b...),Health

With the completion of this latest study and the current dossier of data the company plans to solicit the poultry industry for additional guidance and potential interest and opportunities for developing this compound jointly toward commercialization.

About the study:

This study was conducted by Dr. Mark Jackwood Professor, Department of Population Health, College of Veterinary Medicine, University of Georgia who concluded that based on the results:

-- A 1:20 dilution of QR448(a) given to two week old chickens by aerosol

treatment at a dose of 1ml per bird 2 hours before challenge was

effective in significantly lowering the amount of challenge virus in

the trachea to undetectable levels (less than or equal to 100 EID [for

50%], p less than or equal to 0.2).

-- Aerosol treatment of QR448(a) 2 hours after challenge was effective at

lowering the amount of virus in the trachea to approximately 1 X 10 (to

the 2.5 power) EID (for 50%) (p less than or equal to 0.2), which is

significant, as disease is typically not observed when less than 1 X

10 (to the 3 power) EID (for 50%) is used for challenge.

-- Effective dosing was established between high and low concentrations of

QR448(a). Higher concentrations may have created an environment in the

upper-respiratory tract allowing virus infection to occur. In

addition, the lowest concentrations of QR448(a) appear to be

insufficient for preventing virus infection. The optimum dose was

established in this trial to be 1:20 dilution for success.

Dr. Jackwood stated: "The reduction of clinical signs and detection of fewer virus particles in chickens challenged with an extremely infectious and virulent strain of IBV was quite remarkable. There are many different types of IBV but generally o
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