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QuatRx Pharmaceuticals Announces Presentation of Further Data from Ophena(TM) (Ospemifene) Phase 3 Study for Treatment of Symptoms of Vulvovaginal Atrophy
Date:5/21/2008

life. These results from the Phase 3 clinical trial for Ophena(TM) show that a non-estrogen therapy may provide significant benefits for post-menopausal women affected by vaginal dryness and dyspareunia, two of the most common and debilitating symptoms of vulvovaginal atrophy," said James A. Simon, M.D., CCD, FACOG, Clinical Professor of Obstetrics and Gynecology at the George Washington University.

Ophena(TM) is a novel selective estrogen receptor modulator (SERM) that is being studied as a non-estrogen alternative for the treatment of postmenopausal vaginal syndrome (PVS), also known as vaginal atrophy. The only FDA approved products currently available to treat PVS contain the hormone estrogen. Treatment with estrogen replacement therapy has been associated with certain health risks including an increased risk of breast cancer.

"For women who are concerned about the health risks of estrogen therapy, currently available treatment options for symptoms of vulvovaginal atrophy are limited and inadequate. These study results indicate that Ophena(TM) has the potential to be the first non-estrogen treatment option that provides a clear clinical benefit. We are working to advance the development program for Ophena(TM) to make this important therapy available to all women who would benefit from it," said Robert Zerbe, M.D., president and chief executive officer of QuatRx.

About Postmenopausal Vaginal Syndrome

Postmenopausal vaginal syndrome (PVS) is a chronic and progressive condition characterized by symptoms including vaginal dryness, sexual pain (dyspareunia), and irritation. Declining estrogen levels during menopause can cause tissues of the vaginal lining to grow thinner and to lose elasticity, a condition known as atrophy. Dryness and irritation associated with reductions in vaginal secretions often cause pain or bleeding during sexual intercourse. The decline in estrogen also contributes to an increase in vaginal pH, creating an environ
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SOURCE QuatRx Pharmaceuticals
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