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Quark Pharmaceuticals to Present Data on its siRNA Therapeutic Programs in Kidney and Lung Diseases
Date:11/2/2009

he first systemically administered siRNA, as well as additional pre-clinical stage compounds, through important value-enhancing milestones in 2010. We look forward to presenting these case studies reflecting the success of our proprietary programs."

QPI-1002 targets p53, a stress-response gene that plays a pivotal role in the apoptotic pathway. Temporary inhibition of p53 at the time of injury delays cell death, allowing natural repair mechanisms to restore normal DNA and cellular integrity. QPI-1002 is currently being evaluated in a Phase I/IIa clinical study for the prevention of acute kidney injury (AKI) and in Part A of a Phase I/II clinical study for the prophylaxis of delayed graft function (DGF) following renal transplantation. Both studies are scheduled to be completed this year.

About Quark Pharmaceuticals, Inc.

Quark Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company engaged in discovering and developing novel RNAi-based therapeutics. Quark has a fully integrated drug development platform that spans therapeutic target identification to drug development. Quark's RNAi technology includes novel siRNA structures and chemistry providing Quark with freedom to operate in the siRNA intellectual property arena, as well as the ability for non-invasive delivery of siRNA to target tissues and organs including the eye, ear, lung, spinal cord and brain.

Quark's clinical pipeline includes PF-4523655 (RTP801i-14), currently in Phase II clinical trials for Diabetic Macular Edema (DME) and Age-related Macular Degeneration (AMD). PF-4523655 is a synthetic, chemically modified siRNA designed to inhibit the expression of the gene RTP801 discovered by Quark through the gene discovery platform BiFAR. PF-4523655 is licensed to Pfizer. In addition, Quark's current clinical pipeline includes QPI-1002, the first systemically administered siRNA drug in human clinical trials, developed by Quark for the prevention of acu
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SOURCE Quark Pharmaceuticals, Inc.
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