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Quark Pharmaceuticals Reports Favorable Interim Results from Phase I Clinical Study of QPI-1007 in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
Date:1/4/2012

three months of follow up, for which historical data are available, the percentage of patients gaining three or more lines was 50-55% in both dosing cohorts. These values are higher than historical data reported in two different published clinical studies exploring the natural course of the disease where only 39 or 20% of patients, respectively, gained 3 or more lines at 3 months after disease onset(1). In the latter case, the advantages of treatment with QPI-1007 were strongly significant. Furthermore, at 1 month after the administration of QPI-1007, patients gained on average 13 and 16 letters in the two dose groups. At 3 months, average letter gain was 14 in both groups and none of the patients lost vision compared to screening data.  A change of 15 letters is considered to be a substantial improvement in visual acuity. Evaluation of these patients is ongoing, with additional assessments planned at six- and 12-months post-injection.

"We are very encouraged by these interim clinical data. The data suggest that QPI-1007 may improve visual acuity in NAION patients.  Based on the interim data from this clinical study, and from our positive results from preclinical studies in three different models of optic neuropathy, including a model of glaucoma, we believe QPI-1007 may protect neurons in the retina and optic nerve in NAION and in other types of optic neuropathy, the most common of which is glaucoma," said Dr. Daniel Zurr, Quark's Chief Executive Officer. "QPI-1007 represents Quark's first drug with proprietary RNAi structure, and we believe these interim results support our position as a world leader in the discovery and development of RNAi-based therapeutics."

About NAION

Non-arteritic ischemic optic neuropathy (NAION) is the most common cause of sudden optic nerve-related vision loss. NAION is an acute ischemic disorder believed to be caused by insufficient arterial blood flow to the optic nerve via the posterior c
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SOURCE Quark Pharmaceuticals, Inc.
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