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Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
Date:8/27/2007

work through the recently discovered cellular mechanism known as RNA interference, or RNAi. Quark is able to discover novel therapeutic targets based on its proprietary gene discovery platform, BiFAR(TM). This, combined with its ability to design and successfully deliver synthetic molecules of the new class of RNAi therapeutics known as small-interfering RNA, or siRNA, to specific organs in the body, enables the Company to rapidly develop drug candidates. Quark has two internally discovered and developed lead candidates: RTP801i-14 in Phase 1 clinical trial for the treatment of wet age-related macular degeneration, and AKIi-5 for the prevention of acute renal failure. The Company has out-licensed certain siRNA drug candidates to Pfizer on an exclusive worldwide basis. These drug candidates are designed to inhibit Quark's proprietary target gene RTP801, including RTP801i-14. Quark has, in addition, a product candidate portfolio of RNAi therapeutics based on novel targets and therapeutic concepts discovered using BiFAR(TM) and designed for the treatment of oxidative stress associated diseases of the inner ear, lungs and additional organs of the body.

Quark is headquartered in Fremont, California and operates research and development facilities in Boulder, Colorado and Ness-Ziona, Israel. Additional information is available on the Company website at http://www.quarkpharma.com.

Forward-looking statement

Various statements in this release concerning the Company's future expectations, plans and prospects, including its intention to publicly offer shares of its common stock, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including risks related to fluctuations in our sto
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SOURCE Quark Pharmaceuticals, Inc.
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