Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute He...(id We are encouraged bythe advancement ...),Health

Date:8/20/2007

id, "We are encouraged by the advancement of AHLi-11 for acute hearing loss and look forward to filing an IND by year-end for the prevention of chemotherapy-induced hearing loss. Up to a million people per year are treated with cisplatin in the US and Europe, and the risk of serious hearing impairment is particularly devastating in children. With this in mind, Quark will continue its efforts to advance AHLi- 11 in response to this major unmet medical need.

"We are also thrilled to expand our relationship with Professor Salvi and his colleagues at the State University of New York as it will enable us to deepen our understanding of the molecular processes underlying acute hearing loss and to examine several variables related to the impact of AHLi-11 as a curative measure. Our collaborations with leading academic institutions mark the ongoing development of our pipeline and reinforce Quark's expertise in the development of siRNA-based therapeutics that offer the potential to treat a wide range of disease targets."

About AHLi-11

AHLi-11 is a synthetic siRNA that is a temporary and reversible suppressor of p53, and contains the same active compound as AKIi-5, Quark's drug candidate for the prevention of acute renal failure. AHLi-11 is in development for the prevention of acute hearing loss, initially induced by the ototoxic cancer therapeutic agent cisplatin. AHLi-11 is based on Quark's proprietary, patented concept of temporary and reversible inhibition, for therapeutic purposes, of the expression of the transcription factor human p53, which is associated with DNA repair and apoptosis. In response to certain chemotherapeutic agents, such as cisplatin and carboplatin, molecular mechanisms, most likely associated with p53-dependent stress response, are suspected of triggering cochlear hair cell apoptosis. Temporary inhibition of p53 prevents apoptosis, allowing restoration of normal DNA and cellular integrity. The AHLi-11 active molecule was designed and
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SOURCE Quark Pharmaceuticals, Inc. Copyright©2007 PR Newswire.

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