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Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
Date:8/20/2007

Quark's First Hearing Loss Compound, AHLi-11, Slated for IND Filing By

Year- End 2007

FREMONT, Calif., Aug. 20 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on discovering and developing novel RNA interference-based therapeutics, announced today that it has expanded its relationship with the State University of New York at Buffalo, Center for Hearing & Deafness, which is the Company's primary site for the pre-clinical studies of its product candidate, AHLi-11, for the treatment of acute hearing loss. Quark initiated its collaboration with the State University of New York in 2005.

The current studies, led by Professor Richard Salvi, focus on the in-depth analysis of the effect of AHLi-11 and other molecules in preventing chemotherapy induced hearing loss. Based on these studies, Quark Pharmaceuticals expects to file an IND within 2007 for AHLi-11 for the prevention chemotherapy-induced hearing loss.

AHLi-11 is a siRNA-based drug that temporarily inhibits the expression of human gene p53. Cochlear hair cell apoptosis (cell death), a key factor in several of the more common causes of acute hearing loss, is believed to be induced by molecular mechanisms most likely associated with p53-dependent stress response. Inhibition of p53, therefore, is suggested as a potential modality for the prevention of ototoxic hearing loss, a common side effect of certain drugs including aminoglycoside antibiotics and cancer therapeutics such as cisplatin, as well as acoustic trauma.

Quark has demonstrated delivery of siRNA into target cells in rats and monkeys along with its persistence in the cochlear hair cells for at least 15 days. In preclinical animal studies, AHLi-11 appears to protect cochlear hair cells from apoptotic cell death induced by the chemotherapeutic agents, cisplatin and carboplatin, and by acoustic trauma.

Daniel Zurr, CEO of Quark Pharmaceuticals, sa
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SOURCE Quark Pharmaceuticals, Inc.

Copyright©2007 PR Newswire.

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