Navigation Links
Quark Pharmaceuticals Expands International Patent Protection for Compounds Targeting the RTP801 Gene

FREMONT, Calif. Oct. 26 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced issuance of Japanese Patent Number: 4354633, titled, "Hypoxia regulated genes," on August 7, 2009. Granted to Quark from a Japanese National Phase application of International (PCT) Patent Application No. PCT/US98/17296, the patent corresponds to U.S. Patent No.s 6,455,674, 6,555,667 and 6,740,738 issued by the United States Patent and Trademark Office.

The granted claims broadly cover various aspects of the RTP801 gene, including inhibitors targeting either the mRNA or peptide products of the gene. This patent is part of the intellectual property estate that is the basis of PF-4523655 (formerly RTP801i-14), a synthetic siRNA molecule licensed to Pfizer on an exclusive worldwide basis that is designed to inhibit the expression of RTP801 and is being evaluated in clinical studies for the treatment of Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD). PF-4523655 is currently in Phase II clinical studies for DME and for wet AMD.

By targeting the RTP801 gene, PF-4523655 has been shown to inhibit abnormal blood vessel growth and leakage, and to reduce inflammation and suppress apoptosis in animal models of retinal diseases. Importantly, RTP801 inhibition differentiates PF-4523655 from other therapeutics designed to specifically inhibit angiogenesis by targeting either VEGF or its receptors, because it acts via a VEGF-independent pathway. Hence, PF-4523655 has the potential to show efficacy when used either as a monotherapy or in combination with existing VEGF-based therapies.

Daniel Zurr, Ph.D., President and Chief Executive Officer of Quark, said, "Patents are essential in the drug development process as they protect the significant investments in R&D and regulatory activities necessary to obtain marketing approvals and to generate commercial sales. We are vigilant about upholding our industry leadership position in siRNA R&D by protecting our pipeline with an aggressive and comprehensive approach to intellectual property generation and management. . We are also focused on broadening our intellectual property estate to further protect and enhance the value of our product pipeline."

About the PF-4523655 (RTP801i-14) Clinical Program

PF-4523655 (RTP801i-14) is a synthetic, siRNA molecule designed to inhibit the expression of Quark's proprietary target, RTP801. The product candidate is licensed to Pfizer on an exclusive worldwide basis. Quark discovered RTP801 using its BiFAR(TM) target discovery platform, which identifies clinically relevant genes and proteins that are critical to reversing a given disease phenotype when inhibited. The Company owns a family of patents covering the RTP801 gene and protein sequences, specific antibodies, and gene inhibition across different disease indications.

The ongoing Phase II study is a prospective, randomized, multi-center, dose-ranging study is designed to evaluate the safety and efficacy of PF-4523655 versus laser therapy in 160 patients with DME. In this study, patients are randomized to receive intravitreal injections of one of three dose levels of PF-4523655, or laser therapy. Therapeutic effect will be evaluated by assessing visual acuity and retinal morphology.

About Quark Pharmaceuticals, Inc.

Quark Pharmaceuticals, Inc. is a development-stage pharmaceutical company engaged in discovering and developing novel RNAi-based therapeutics. Quark has a fully integrated drug development platform that spans therapeutic target identification to drug development. Quark's RNAi technology includes novel siRNA structures and chemistry providing Quark with freedom to operate in the siRNA intellectual property arena, as well as the ability for non-invasive delivery of siRNA to other target tissues including the eye, ear, lung, spinal cord and brain.

In addition to PF-4523655, Quark's current clinical pipeline includes QPI-1002, the first systemically administered siRNA drug in human clinical trials, developed by Quark for the prevention of acute kidney injury (AKI) following major cardiovascular surgery and the prophylaxis of delayed graft function after kidney transplantation. Quark has licenses from Silence Therapeutics and from Alnylam Pharmaceuticals for the structure of these products.

QPI-1007, a siRNA that utilizes a proprietary structure developed by Quark, is being evaluated in advanced IND-enabling preclinical studies as a neuroprotective agent in eye diseases. In addition, Quark has a broad pipeline of siRNA drug candidates based on novel structures developed internally. The Company expects to utilize the structures to develop additional RNAi drug candidates.

Quark is headquartered in Fremont, California and operates research and development facilities in Boulder, Colorado and Ness-Ziona, Israel. Additional information is available at

    Quark Pharmaceuticals, Inc.         The Ruth Group (investors / media)
    Juliana Friedman                    Sara Ephraim / Janine McCargo
    +972 89 30 5111                     (646) 536-7002 / 7033 

SOURCE Quark Pharmaceuticals, Inc.

SOURCE Quark Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
2. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
3. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
4. Quark Pharmaceuticals Appoints New Chief Medical Officer
5. Quark Pharmaceuticals Signs Collaboration Agreement With University of Michigan for Development of Proprietary SiRNA Compounds for Noise-Induced Hearing Loss
6. Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans
7. Quark Pharmaceuticals Announces First Patient Dosing by Pfizer in Phase II Trial of RNAi Therapy in Diabetic Macular Edema
8. Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial
9. Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property
10. Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy
11. Quark Pharmaceuticals Announces Dosing of the First Patient in Phase I/II Clinical Trial for Systemically Delivered siRNA Drug Candidate for Delayed Graft Function
Post Your Comments:
(Date:11/30/2015)... BOSTON , Nov. 30, 2015  Kevin ... of Sensium Healthcare, a global pioneer in wireless ... Boston, MA , Mr. Smith ... of Sensium,s global commercial strategy.  He will also ... universities, to build clinical evidence for SensiumVitals, the ...
(Date:11/30/2015)... , Nov. 30, 2015  PTS Diagnostics, the ... CardioChek ® analyzers, A1CNow ® systems, and ... a family of patents that will propel the company ... and Europe . The technology ... such as those on smartphones and tablets, and uses ...
(Date:11/30/2015)... and ST. LOUIS , ... Scripts (NASDAQ: ESRX ) today announced an early ... partnership, which began in 1999, will now extend through ... --> After evaluating pharmacy benefit manager capabilities ... that Express Scripts continues to offer the best health ...
Breaking Medicine Technology:
(Date:11/30/2015)... ... 2015 , ... Since its inception, Seniors Guide has been ... living and all other retirement options. Support for issues surrounding the senior community ... top priority. , So it’s no surprise that every November, Seniors Guide ...
(Date:11/30/2015)... ... November 30, 2015 , ... Holcomb – Kreithen ... plastic surgery practices in Florida, is proud to announce that Dr. Joshua Kreithen, ... giant Ethicon Inc., a Johnson & Johnson Company. , Ethicon is a global ...
(Date:11/30/2015)... ... , ... Sikka Software announced today that they are showcasing the Sikka Software ... complex business decisions by providing the tools and information they need to grow their ... procedures customized by zip code. , The Sikka Software Ecosystem includes over 32 ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... verified that their Vasont Universal Integrator (VUI) extension unites with Syncro Soft’s latest ... managing content as a continuous process with the latest release of oXygen® XML ...
(Date:11/30/2015)... Phoenixville, PA (PRWEB) , ... November 30, 2015 ... ... all of the assets of DataTrade Solutions Inc., a Healthcare IT consulting, development ... by utilizing the programming and technical experience available within DataTrade to extend the ...
Breaking Medicine News(10 mins):