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Quark Pharmaceuticals Appoints New Chief Medical Officer
Date:9/4/2007

1i-14, a siRNA compound for the treatment of wet age- related macular degeneration exclusively licensed to Pfizer. The Company expects to complete this trial and to initiate a Phase I trial of its second siRNA compound, AKIi-5, for the prevention of acute renal failure in the second half of 2007. Additionally, Quark is conducting preclinical studies of its proprietary compound, AHLi-11, for the treatment and prevention of acute hearing loss associated with acoustic trauma and cancer therapeutics. The Company expects to file an IND within 2007 for AHLi-11 for the prevention of chemotherapy-induced hearing loss.

About Quark Pharmaceuticals, Inc.

Quark Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing novel therapeutics based on its proprietary gene discovery science and technology, with an initial focus on drug candidates that work through the natural mechanism in the cell known as RNA interference, or RNAi, for the treatment of diseases associated with oxidative stress. Quark believes that its proprietary target gene discovery platform, BiFAR(TM), combined with its ability to design and successfully deliver synthetic molecules of the new class of RNAi therapeutics known as small-interfering RNA, or siRNA, to specific organs in the body, enables the Company to rapidly develop drug candidates. Quark has two internally discovered and developed lead product candidates: RTP801i-14 in phase I/IIa clinical trial for the treatment of wet age-related macular degeneration, and AKIi-5 for the prevention of acute renal failure. The Company has licensed RTP801i-14 to Pfizer on an exclusive worldwide basis. Quark has, in addition, a product candidate portfolio of RNAi therapeutics based on novel targets and therapeutic concepts discovered using BiFAR(TM) and designed for the treatment of oxidative stress associated diseases of the inner ear, lungs and additional organs of the body.

Quark is headquartered in
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SOURCE Quark Pharmaceuticals, Inc.
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