Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Ch...(th whom we haveestablished a very produc...),Health

Date:10/12/2008

th whom we have established a very productive collaboration. The results of the present study reconfirm our interest in the target and provide for new product opportunities within our expanding siRNA product pipeline. Quark has the deepest clinical-stage pipeline of siRNAs under development, with efficacy studies completed for several compounds, many stemming from our internal gene discovery programs, and ongoing research efforts to further broaden our range of siRNA product candidates."

Professor Shyam Biswal of the Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, principal investigator of the study said, "RNAi-mediated reduction of Nrf2 expression represents a potential breakthrough for treating non-small cell lung cancer. Suppression of Nrf2 effectively inhibited tumor growth and increased sensitivity to chemotherapeutic drug-induced cell death in the study. It is critical that we establish new and effective therapies for NSCLC, which is intrinsically resistant and generally nonresponsive to initial chemotherapy, and commonly leads to acquired resistance even as therapies become increasingly sophisticated. We are encouraged by Quark's continued evaluation and development of therapeutics that target Nrf2 to inhibit tumor growth and circumvent chemoresistance."

Quark Pharmaceuticals has recently announced QPI-1007, its first drug candidate to utilize a novel siRNA structure developed by Quark with freedom to operate in the siRNA intellectual property space. QPI-1007 is currently being evaluated in advanced IND-enabling preclinical studies as a neuroprotective agent for eye diseases.

The publication can be seen online at http://cancerres.aacrjournals.org/cgi/content/abstract/68/19/7975.

About Quark Pharmaceuticals, Inc.

Quark Pharmaceuticals, Inc. is a development-stage pharmaceutical compan
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