Navigation Links
Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy
Date:10/12/2008

Quark siRNAs Examined Alone and in Combination with Chemotherapy

FREMONT, Calif. Oct. 12 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that the journal Cancer Research published results on efficacy of siRNA targeting its proprietary target gene against non-small cell lung cancer (NSCLC) in the edition dated October 1, 2008. The paper, entitled "RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy," reports on research performed in collaboration with Professor Shyam Biswal of the Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University. The results provide a basis for a potential new drug candidate to be added to Quark's pipeline.

The study examined efficacy of RNAi-mediated reduction of Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) expression in vitro and in in vivo mouse NSCLC xenograft models alone or in combination with chemotherapy. The results show that RNAi-mediated reduction of Nrf2 expression generates reactive oxygen species, suppresses tumor growth, and increases sensitivity to chemotherapeutic drug-induced cell death.

Elena Feinstein, M.D., Ph.D., Chief Scientific Officer of Quark Pharmaceuticals, said, "Nrf2 appears in our IP portfolio as a novel drug target for cancer treatment. Discovery of the target's role in cancer was made years ago, using our proprietary functional high throughput drug target discovery method, BiFAR(TM), when we looked for genes whose inhibition could sensitize cancer cells to apoptosis. Since then, much progress has been made to study the concept of Nrf2 inhibition for cancer treatment by the scientific community. One of the major contributors in this field is Prof. Biswal from Johns Hopkins University wi
'/>"/>

SOURCE Quark Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
2. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
3. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
4. Quark Pharmaceuticals Appoints New Chief Medical Officer
5. Quark Pharmaceuticals Signs Collaboration Agreement With University of Michigan for Development of Proprietary SiRNA Compounds for Noise-Induced Hearing Loss
6. Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans
7. Quark Pharmaceuticals Announces First Patient Dosing by Pfizer in Phase II Trial of RNAi Therapy in Diabetic Macular Edema
8. Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial
9. Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property
10. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
11. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... LONDON , April 21, 2015 ... for Enterprise, having achieved dazzling export-led growth in ... London™ today celebrates its part in winning the ... International Trade, awarded to Oxford PharmaGenesis. As part ... London helps its clients bring new medicines to ...
(Date:4/21/2015)... -- This report analyzes the worldwide markets for Apheresis ... for Therapeutic Apheresis, and Equipment for Donor Apheresis. Global ... Plateletpheresis, and Others. The report provides separate comprehensive analytics ... Japan , Europe , ... Annual estimates and forecasts are provided for the period ...
(Date:4/21/2015)... -- Cardiologists at Henry Ford Hospital have implanted a device ... irregular heartbeat. With only handful of hospitals in ... able to add another option to its arsenal of tools ... ability to pump. "This is a first ... implant at a non-clinical trial site," says cardiologist Claudio ...
Breaking Medicine Technology:Queen's Award Crowns Achievements of Fast-growing London Consultancy 2Queen's Award Crowns Achievements of Fast-growing London Consultancy 3Queen's Award Crowns Achievements of Fast-growing London Consultancy 4Queen's Award Crowns Achievements of Fast-growing London Consultancy 5World Apheresis Equipment Industry 2World Apheresis Equipment Industry 3World Apheresis Equipment Industry 4World Apheresis Equipment Industry 5World Apheresis Equipment Industry 6World Apheresis Equipment Industry 7World Apheresis Equipment Industry 8World Apheresis Equipment Industry 9World Apheresis Equipment Industry 10World Apheresis Equipment Industry 11World Apheresis Equipment Industry 12World Apheresis Equipment Industry 13World Apheresis Equipment Industry 14World Apheresis Equipment Industry 15World Apheresis Equipment Industry 16World Apheresis Equipment Industry 17World Apheresis Equipment Industry 18World Apheresis Equipment Industry 19World Apheresis Equipment Industry 20World Apheresis Equipment Industry 21Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 2Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 3
... Jan. 10 Patients who received,OrbusNeich,s pro-healing stent, ... cardiac adverse events (MACE) than patients who,received Boston ... in a study conducted at Federico II University ... study were presented recently,at the XXVIII National Congress ...
... Age, Becomes Squarer, Makes You Look Older, ASPS,Study Reveals, ... be giving away your age, and it has nothing ... study in January,s Plastic and,Reconstructive Surgery(R) (PRS), the official ... found that as we age, the,lower jaw continues to ...
Cached Medicine Technology:OrbusNeich's Genous(TM) Bio-engineered R Stent(TM) has Lower MACE Rate than TAXUS(R) and CYPHER(R) Stents in Clinical Trial 2Looking Older? How Square is Your Jaw Line? 2
(Date:4/21/2015)... (PRWEB) April 21, 2015 Top medical ... in India for their ongoing commitment to providing superior ... strives to provide patients with the best possible experience ... skin, hair and body. , Executives at Ojas Aesthetic ... the philosophy of — nothing about you, without you ...
(Date:4/21/2015)... Jersey City, NJ (PRWEB) April 21, 2015 ... enterprise collaboration across platforms and devices, today announced a ... the integration of the new Microsoft Office 365 Management ... that allows customers to fully audit and take action ... 365 environments. , “The new Office 365 Management Activity ...
(Date:4/21/2015)... WA (PRWEB) April 21, 2015 ... Practice Edition 2 for otolaryngologists, bringing the most ... the healthcare community. Otolaryngologists can now experience ... by a trusted source in the industry, Lyft, ... integration with leading EHRs. , “Lyft is very ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 Edward ... and Arthur “A.G.” Kawamura, former Secretary of the California ... featured speakers for the 2nd Annual GrowRIVERSIDE Conference: The ... , The inclusion of these nationally known experts ... experts, city planners, farmers and others slated to speak ...
(Date:4/21/2015)... Further strengthening ties between the two institutions, ... goods and services to the University of South Florida ... BRIDGE Healthcare Clinic. , The BRIDGE clinic – a ... year – provides primary medical care to more than ... inside the USF Health Morsani Center for Advanced Healthcare. ...
Breaking Medicine News(10 mins):Health News:VisitandCare.com Cosmetic Surgery Provider in India Earns Recognition for Patient Satisfaction 2Health News:VisitandCare.com Cosmetic Surgery Provider in India Earns Recognition for Patient Satisfaction 3Health News:AvePoint Integrates Microsoft Office 365 Management Activity API into DocAve Policy Enforcer for Proactive SharePoint Monitoring 2Health News:AvePoint Integrates Microsoft Office 365 Management Activity API into DocAve Policy Enforcer for Proactive SharePoint Monitoring 3Health News:Lyft Expands Its Offerings to Include Dragon® Medical Practice Edition 2 for Otolaryngologists. 2Health News:USDA Under Secretary, former CA Agriculture Director to Address 2nd Annual “GrowRIVERSIDE” Conference in June 2Health News:USDA Under Secretary, former CA Agriculture Director to Address 2nd Annual “GrowRIVERSIDE” Conference in June 3Health News:USF Health and Florida Hospital Tampa Partner to Expand BRIDGE Clinic 2Health News:USF Health and Florida Hospital Tampa Partner to Expand BRIDGE Clinic 3
... the insulin gene to diabetes patients using nanoparticles, was presented ... Society of Gene Therapy (ASGT) in Seattle. ,Type ... the insulin producing pancreatic -cells. As a result of the ... damage to fine blood vessels and nerve endings leading to ...
... with culture-positive tuberculosis (TB), relapse rates were found ... compared to HIV-uninfected patients following a rifamycin-based regimen. ... patients who received intermittent or standard 6-month therapy ... treatment. ,The results appear in the ...
... But one should pop the pill just before sex. The ... good news for those suffering from erectile dysfunction (ED) - ... than the pills. ,Human and animal trials suggest ... treatments available. A University of Pittsburgh team, led by Dr ...
... CHICAGO:- Scientific advances have enabled better diagnosis and treatment ... presented at the world's premier conference on cancer. "We've ... unique to women," Julie Gralow, assistant professor of oncology ... ,"The studies discussed today bring us even closer ...
... CHICAGO, Bayer HealthCare Pharmaceuticals Inc. and Onyx Pharmaceuticals, ... extended overall survival in patients with hepatocellular ... taking placebo by 44%. Results were presented at ... of Clinical Oncology (ASCO). ,The international, ...
... new climate plan of the US should complement rather than ... Climate Change (UNFCCC), China's top economic planner Ma Kai ... common but differentiated responsibilities in the UNFCCC and some details ... other countries, Ma said at a press conference. ...
Cached Medicine News:Health News:Novel Delivery Method of Insulin Gene to Combat Juvenile Diabetes Developed 2Health News:Treatment Outcomes of Patients With HIV and Tuberculosis 2Health News:Gene Therapy a Better Alternative to Viagra Please 2Health News:Advanced Scientific Brings Help for Breast Cancer Survivors 2Health News:Nexavar Significantly Extends Survival of Liver Cancer Patients 2
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTP/1Q-PAL chairs are recommended for the ... room, static control, health care and ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With polished ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTN/1Q-CAB chairs are recommended for ... clean room, static control, health care ...
Medicine Products: