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Quark Pharmaceuticals Announces First Patient Dosing by Pfizer in Phase II Trial of RNAi Therapy in Diabetic Macular Edema
Date:7/30/2008

Officer of Quark, commented, "The progression of PF-4523655 into Phase II further supports our integrated RNAi approach that leverages our internal BiFAR target discovery platform. In addition, Pfizer's interest demonstrates the viability of RTP801 as a potential target for ophthalmic indications. We look forward to continuing our relationship with Pfizer throughout later stages of clinical development and intend to fully collaborate towards the potential commercialization of PF-4523655 in diabetic macular edema, age-related macular degeneration, and other ophthalmic indications covered in our agreement."

Dario Paggiarino, Executive Director Clinical Development of Pfizer Inc, stated, "Our collaboration with Quark is a prime example of Pfizer's commitment to the research and development of innovative therapies with the potential to preserve sight and improve patient outcomes in ophthalmology. This research is important because not all patients with retinal disease benefit from currently available treatments."

Results from a Phase I/II trial completed by Quark on Pfizer's behalf showed that PF-4523655 was safe and well tolerated in patients with wet age-related macular degeneration (wet-AMD) who failed to respond to currently approved therapies. Based on data from this trial, Pfizer decided to pursue a Phase II trial in DME. In addition, Quark and Pfizer are considering an additional Phase II study of PF-4523655 in patients with wet-AMD.

About the PF-4523655 (RTP801i-14) Clinical Program

PF-4523655 (RTP801i-14) is a synthetic, siRNA molecule designed to inhibit the expression of Quark's proprietary target, RTP801. The product candidate is licensed to Pfizer on an exclusive worldwide basis. Quark discovered RTP801 using its BiFAR target discovery platform, which identifies clinically relevant critical genes and proteins that reverse the disease phenotype when inhibited. The Company owns a family of patents covering the RTP801 gene, its RN
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SOURCE Quark Pharmaceuticals, Inc.
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