Navigation Links
Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
Date:8/19/2007

kidney injury caused by ischemia-reperfusion. Our drug could potentially offer a lifesaving treatment for this severe disease, which exhibits high rates of morbidity and mortality and represents a very serious unmet medical need. We have an open IND for AKIi-5 and expect to initiate a Phase I trial for the prevention of ARF through the systemic delivery of AKIi- 5 in patients undergoing major cardiac surgery. Based on publicly available information, we believe that this will be the first human clinical trial involving the systemic delivery of siRNA."

About AKIi-5

AKIi-5 is a synthetic, chemically modified siRNA molecule designed to temporarily inhibit the expression of p53, a gene which plays a significant role in ARF by inducing tubular cell death (apoptosis) in response to injury. AKIi-5 is based on Quark's proprietary, patented concept of temporary and reversible inhibition, for therapeutic purposes, of the expression of the transcription factor human p53, which is associated with DNA repair and apoptosis. Using RNA interference technology to temporarily inhibit p53 in acute settings such as acute kidney injury, apoptosis is delayed thereby allowing natural repair mechanisms to restore normal DNA and cellular integrity. The AKIi-5 molecule was designed and patented by Quark. The Company has licenses for AtuRNAi(TM) technology from Silence Therapeutics and additional RNAi intellectual property from Alnylam.

About Acute Renal Failure (ARF)

ARF is a syndrome characterized by a rapid decline of kidney function leading to death in a high percentage of cases. Major cardiac surgery is one of the many causes of ARF. During cardiac bypass surgery, lack of oxygen caused by reduced local blood flow to the kidneys, followed by rapid reintroduction of oxygen, or reperfusion, to the kidneys upon removal of the patient from cardiopulmonary bypass, initiates a chain of events that can lead to ARF. Currently, there are no approved drug therapies that effec
'/>"/>

SOURCE Quark Pharmaceuticals, Inc.

Copyright©2007 PR Newswire.

Page: 1 2 3 4

Related medicine technology :

1. Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple Myeloma and Waldenstroms Macroglobulinemia
2. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois
3. Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data on Molecular Imaging Pharmaceutical for Prostate Cancer
4. Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data at Society Of Nuclear Medicine 2007 Annual Meeting
5. CytRx Announces RNAi Delivery Nanoparticle Technology Exclusively Licensed to Subsidiary, RXi Pharmaceuticals, Described in Peer-Reviewed Journal
6. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
7. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
8. Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology
9. Clinical Data From Nymox BPH Drug To Be Presented at American Urological Association Meeting
10. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
11. ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data Presented at International Myeloma Workshop
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... DALLAS , Jan. 15, 2014 /PRNewswire-iReach/ -- ... research report to its store . ... from aging of population, consumption upgrade and policy ... industry has seen rapid development over the years, ... yuan in 2006 to 9.85 billion yuan in ...
(Date:1/15/2014)... AARP Foundation today announced it has established a ... the severe cold weather that has gripped much of ... helping those in need; so to support these emergency ... contributions up to $250,000, which could mean up to ... through AARP Foundation. (Logo: http://photos.prnewswire.com/prnh/20070209/NYF043LOGO ...
(Date:1/15/2014)... 2014 Shire plc (LSE: SHP, NASDAQ: ... Office of Fair Trading (OFT) approval condition to the announced ... Incorporated (NASDAQ: VPHM).   As a result of ... approval, and Shire expects to complete the tender offer on ... to the satisfaction of all of the remaining conditions to ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... 30 Wound Care,Innovations, LLC, a subsidiary of ... today that it will attend and exhibit at,the ... Boston. This,seminar is presented by HMP Communications, the ... and producers of the Symposium on,Advanced Wound Care. ...
... NIH; Findings could benefit,pregnant women worldwide, SEATTLE, ... and Human Development division of the National Institutes ... a $2.9 million grant,for a five-year research project ... known as preeclampsia and migraine., Dr. Williams ...
Cached Medicine Technology:Wound Management Technologies, Inc. Announces Conference Plans in Boston and Additional Clinical Research on CellerateRx(R) 2Swedish in Seattle to Study Connections Between Preeclampsia and Migraine 2Swedish in Seattle to Study Connections Between Preeclampsia and Migraine 3
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... , NEW ORLEANS, July 14 Ochsner Medical Center ... in Louisiana, and one of only a handful in the nation. ... living-donor kidney transplants easier on the donor by using smaller incisions, ... the operation in July 2009 with successful outcomes for the recipient ...
... study found that the clinical criteria for mild ... Alzheimer,s disease than a single memory test. This ... identification and early treatment of individuals most likely to develop ... Association International Conference on Alzheimer,s Disease on July 14 in ...
... 19th century infant deaths attributed to smothering and overlaying, ... likelihood crib deaths, or Sudden Infant Death Syndrome (SIDS). ... neglect and even infanticide, because SIDS had not yet ... researcher from Scottsdale, Arizona, USA. Her findings (1) are ...
... , , WASHINGTON, July 14 Amanda Crawford ... 45, she still smokes despite having tried to quit multiple times. Children are ... smokes - and in Crawford,s case, it was her father who smoked. Born ... smoker - in Roanoke. The Crawfords now have three sons - 28, 14 ...
... , , , , ... announces the launch of HealthPROSe ... a new and trusted voice on health policy and related socioeconomic issues. ... debate with engaging, focused commentaries on national and global health policy concerns. ...
... , SAN DIEGO, July 14 ... inhibitor, prasugrel (Effient), Accumetrics, Inc. announces that its VerifyNow P2Y12 ... but also its newly approved competitor, Effient. In obtaining a ... to determine the response of an individual patient to their ...
Cached Medicine News:Health News:Ochsner 1st in Louisiana to use Robotics in Living-Donor Kidney Transplant for Faster Recovery 2Health News:Mayo Clinic study continues to refine most effective methods to predict Alzheimer's disease 2Health News:New Survey Highlights Emotional, Financial Toll Multi-Generational Tobacco Use Takes on Parents Sandwiched In Between 2Health News:New Survey Highlights Emotional, Financial Toll Multi-Generational Tobacco Use Takes on Parents Sandwiched In Between 3Health News:New Survey Highlights Emotional, Financial Toll Multi-Generational Tobacco Use Takes on Parents Sandwiched In Between 4Health News:HealthPROSe Brings Creative, Strategic Thinking to Health Blogosphere 2Health News:Accumetrics' VerifyNow(R) P2Y12 Test Provides Physicians With Information to Assess a Patient's Response to Newly-Approved Prasugrel (Effient(R)) 2
... onboard rail clamps mount ... tables and stretchers. The ... need for lifting. Easy ... stable surface combined with ...
The DHS Basic Set is available with either self-tapping or non-self-tapping screws. Either instrument set provides complete instrumentation in one graphic case for use with the Universal Implant Set,...
... is a versatile, fully powered orthopaedic and ... traction facilities, a powered centre break and ... versatile too. ,<br.,In fact the RX600 is ... it is for traction procedures. The RX600 ...
... orthopedic trauma procedures. Part of the ... trauma table top provides a complete, ... positioning and provides for skin or ... hip pinnings; femur, supine or lateral ...
Medicine Products: