Navigation Links
Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans
Date:11/19/2007

ay be even more noteworthy as it represents the first documented systemic dosing of siRNA in humans. While the science of RNAi has been well-established, a key step in the acceptance of the technology as a promising therapeutic is the ability to deliver RNAi-based compounds systemically. We look forward to leading this important advance for the industry and, at the same time, continuing the development of this and other siRNA products in our pipeline."

Quark was granted an IND by the Food and Drug Administration (FDA) for AKIi-5 for the prevention of Acute Renal Failure in high-risk patients undergoing major cardiovascular surgery. AKIi-5 is a synthetic, chemically modified siRNA molecule discovered and patented by Quark that has an AtuRNAi technology-based structure licensed from Silence Therapeutics. Quark has also licensed certain intellectual property from Alnylam.

Quark has conducted pre-clinical studies of AKIi-5 for the prevention of acute renal failure in rats and monkeys. Rats treated with a single bolus injection of AKIi-5 were significantly protected from ischemia/reperfusion- induced acute kidney injury. In the rat studies, AKIi-5 effectively prevented the development of acute renal failure. Quark's pharmacokinetic, distribution, and toxicity studies in rats and monkeys indicate that AKIi-5 appears to have a favorable safety profile and has a relatively short residence time in the kidney.

About AKIi-5

AKIi-5 is a synthetic, chemically modified siRNA molecule designed to temporarily inhibit the expression of p53, a gene which plays a significant role in ARF by inducing tubular cell death (apoptosis) in response to injury. AKIi-5 is based on Quark's proprietary, patented concept of temporary and reversible inhibition, for therapeutic purposes, of the expression of the transcription factor human p53, which is associated with DNA repair and apoptosis. The concept was first published by Quark with the University of Illinois in a breakt
'/>"/>

SOURCE Quark Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
2. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
3. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
4. Quark Pharmaceuticals Appoints New Chief Medical Officer
5. Quark Pharmaceuticals Signs Collaboration Agreement With University of Michigan for Development of Proprietary SiRNA Compounds for Noise-Induced Hearing Loss
6. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
7. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
8. Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate
9. Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)
10. Symbollon Pharmaceuticals, Inc. Evaluates the Clinical Effects of IoGen(TM) on Fibrocystic Breast Disease
11. Aegerion Pharmaceuticals, Inc. Presents Final Results of Phase II Clinical Trials for AEGR-733 at Drugs Affecting Lipid Metabolism (DALM) 2007 Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... York , August 4, 2015 ... titled " Non-invasive Prenatal Testing (NIPT) Market (BambniTest, Harmony, ... Others) - Global Industry Analysis, Size, Volume, Share, Growth, ... According to a new market report published by Transparency ... Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ...
(Date:8/4/2015)... Aug. 4, 2015 BioElectronics Corporation (OTC ... Musculoskeletal Pain Therapy medical devices, announced today that ... ActiPatch 7-day trial device has been published in ... Management http://www.futuremedicine.com/doi/full/10.2217/PMT.15.35 .  More than 5,000 ... submitted an assessment.  Chronic pain ...
(Date:8/4/2015)... DUBLIN , Aug. 4, 2015 Research ... of the "Alcohol Ethoxylate Market by Application (Household ... Geographies Global Market Trends, Forecasts to 2019" report ... of alcohol ethoxylate was valued at $5,124.9 million in ... of about 3.5% from 2014 to 2019. The data ...
Breaking Medicine Technology:Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 2Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 3Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 4Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 5BioElectronics' Landmark 5,000+ Chronic Pain Patient Study Published in Pain Management Medical Journal 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 3
... SALT LAKE CITY, May 11, 2011 Dynatronics Corporation (Nasdaq: ... its quarter ended March 31, 2011 during the morning of ... a conference call for investors later that day at 1:00 ... interested in participating should call (800) 926-7510 and use access ...
... 11, 2011 BioSpecifics Technologies Corp. (NASDAQ: ... collagenase-based products, today announced that BioSpecifics, President, Tom Wegman, ... Annual Equity Conference on Tuesday, May 17th at 9:30am ... A live webcast of the presentation can ...
Cached Medicine Technology:
(Date:8/5/2015)... ... August 05, 2015 , ... A group of researchers from ... management of malignant pleural mesothelioma. Details of the research are available on the ... updated guidelines issued by the European Society of Medical Oncology include a recommendation ...
(Date:8/5/2015)... ... August 05, 2015 , ... Social Security benefits are ... in a new survey by The Senior Citizens League (TSCL). The record ... for an estimated 31 million Social Security beneficiaries age 65 and older, says TSCL. ...
(Date:8/5/2015)... , ... August 05, 2015 , ... A leader in ... excited to announce that it has hired Su Barnwell as its new Director of ... faculty management. From 1999 to 2015 she worked for Primary Care Network (PCN) as ...
(Date:8/5/2015)... ... , ... Over 6,500 athletes from 177 nations recently descended upon the Los ... World Games 2015 (July 25 to August 2). , Officially opened by First Lady ... since the 1984 Olympics, and the Los Angeles Coliseum was once again filled up ...
(Date:8/4/2015)... ... August 05, 2015 , ... MONTICELLO, Fla. – After ... and the Tallahassee Memorial Hospital, this journey as a clinician allowed Dr. Barbara ... This journey equipped her to care for patients, families, friends and staff, and she ...
Breaking Medicine News(10 mins):Health News:New Mesothelioma Treatment Guidelines Issued By European Researchers, According to Surviving Mesothelioma 2Health News:Majority of Older Americans Say Social Security Benefits Not Keeping up with Rising Household Costs, According to a New Survey from the Senior Citizens League 2Health News:Majority of Older Americans Say Social Security Benefits Not Keeping up with Rising Household Costs, According to a New Survey from the Senior Citizens League 3Health News:Leading Continuing Medical Education (CME) Provider, Continuing Education Company (CEC), hires expert Su Barnwell as Director of Program Management 2Health News:Leading Continuing Medical Education (CME) Provider, Continuing Education Company (CEC), hires expert Su Barnwell as Director of Program Management 3Health News:CPMA Member Podiatrists Ensure Fit Feet at the Special Olympics World Games in Los Angeles 2Health News:CPMA Member Podiatrists Ensure Fit Feet at the Special Olympics World Games in Los Angeles 3Health News:New book shows how ‘The Presence of a Chaplain’ affects lives 2Health News:New book shows how ‘The Presence of a Chaplain’ affects lives 3
... millions of Americans and is one of the most ... , But researchers now have identified a gene that ... heart muscle and atrial fibrillation (AF).// 'The discovery underscores ... explains Timothy M. Olson, M.D., director of the Cardiovascular ...
... The findings of the preliminary, animal-model study, which ... month in 'Experimental Neurology', has explained on the ... // who are often prescribed such nonsteroidal anti-inflammatory ... ,Because several studies in animals and humans ...
... Periodontal pockets containing specific bacteria and combinations of bacteria ... coronary syndrome (ACS), according to a new study published ... amount of oral bacteria was two times higher in ... streptococci spp, P. gingivalis, T. forsythia and T. denticola. ...
... experience migraines with aura (associated neurologic symptoms such as ... heart// attack, ischemic stroke, angina and death due to ... report a migraine history. In contrast, migraine without aura, ... with increased risk of any cardiovascular event. ...
... For decades, parents and pediatricians have relied on humid air ... a common childhood condition that sometimes// sends worried families to ... that the long relied-on remedy has little medical benefit. ... or shower in the bathroom. Or you get them to ...
... study suggests that eating more fiber and fruit each day ... is based on the results of examining the diets of ... ,The study found that normal weight adults consumed 33 ... than the obese ones. Dietary fiber and complex carbohydrates are ...
Cached Medicine News:Health News:Gene That Causes Atrial Fibrillation Identified 2Health News:Long-term Ibuprofen Therapy After Brain Injury Deteriorate Cognitive Abilities 2Health News:Link between Periodontal Bacteria and Heart Disease Established 2Health News:Migraines with Aura Associated with Increased Risk for Cardiovascular Disease 2Health News:Humid Air is Little Help for Croup's Barking Cough 2Health News:Humid Air is Little Help for Croup's Barking Cough 3
Curved with catch....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Clinical micro clamps by Acland. Matte finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Rhoton #12 straight point needle semisharp, titanium....
Medicine Products: