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Quantum Immunologics, Inc. and the South Alabama Medical Science Foundation Announce an Early Clinical Evaluation of a Novel Immuno-therapeutic Vaccine for Treating Advanced Human Breast Carcinomas
Date:4/29/2008

TAMPA, Fla., April 29 /PRNewswire/ -- Quantum Immunologics, Inc. ("QI") announces the commencement of a Phase I/II clinical trial to assess the safety and efficacy of a novel anti-cancer vaccine/immunotherapy that will be used on patients with Stage IV advanced breast cancer. Patients accepted into the study have previously failed to respond to conventional therapy consisting of surgery, radiation and/or chemotherapy. QI has commissioned the study to be done by the original immunobiologists who developed the experimental immunotherapy. The clinical trial will be part of an FDA-authorized or effective investigator-sponsored Investigational New Drug application (IND).

This immuno-therapeutic experimental "vaccine" developed by scientists at the University of South Alabama (USA) is intended to activate the body's immune system against a cancer-specific protein to destroy the cancer cells. This immunizing protein, called the Oncofetal Antigen (OFA) or immature Laminin Receptor Protein (iLRP), is a universal cancer antigen or protein expressed in all human cancer types tested by the USA scientists thus far. Notably, this specific protein is not expressed on normal cells and tissues and thus is cancer-specific according to available assays.

Those patients with disseminated breast carcinomas and meeting the clinical trial entrance criteria will be treated under the above referenced IND at the Southern Cancer Center (SCC) in collaboration with clinicians at the Providence Cancer Center and other local oncology centers in and around Mobile, Alabama.

The investigators will collect from each patient's blood a white blood cell population called Dendritic Cells (DC). These cells are then exposed in vitro to replicated iLRP, cultured, and reintroduced into the patient via subdermal injection. The hope is that iLRP-sensitized DC will then recognize iLRP as a foreign protein or antigen on cancer cells and, when reintroduced into the body, will then, in t
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SOURCE Quantum Immunologics, Inc.
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