Navigation Links
QRxPharma Successfully Completes Phase 1 Studies for MoxDuo® CR
Date:4/10/2012

rement of opioid blood levels over time revealed a MoxDuo CR profile consistent with expectations for a once to twice-daily formulation.

The second study demonstrated that food consumption does not alter the pharmacokinetic profiles of morphine and oxycodone from MoxDuo CR (30 mg/20 mg) tablets using a two-way crossover design with 17 healthy volunteers. To demonstrate the effects of chronic use on steady-state blood levels, this study also measured the repetitive-dose pharmacokinetic profiles of morphine and its metabolites as well as oxycodone during repetitive (twice daily) administration of MoxDuo CR tablets for 5 days.

The MoxDuo CR tablets used in these clinical tests included QRxPharma's proprietary Abuse Deterrence Formulation (ADF) technology. As an indication of tamper resistance, attempts to extract morphine or oxycodone by crushing and solubilising in water or alcohol resulted in very limited (less than 15%) drug recovery. In addition, the ADF technology did not impair human bioavailability of the opioids following oral administration.

"Clinical performance of the oral MoxDuo CR formulation clearly exceeded our expectations. When directly compared to OxyContin, the largest selling opioid for chronic pain, MoxDuo CR demonstrated superior bioavailabilty and sustained blood levels for over 12 hours, especially in the 12-24 hour time period. At steady-state, MoxDuo CR provided very low fluctuations of oxycodone. MoxDuo CR appears to be a true once or twice a day delivery system for dual opioids," said Dr. Ed Rudnic, Chief Operating Officer, QRxPharma. "We expect that MoxDuo CR's sustained blood levels, ADF attributes and potential side effect benefits will enhance the tolerability and acceptability of MoxDuo CR in the global chronic pain marketplace."

The CR formulation of MoxDuo encompasses the same 3:2 ratio of morphine and oxycodone as in MoxDuo IR, QRxPharma's immediate release acute pain formulation that is scheduled for PDUF
'/>"/>

SOURCE QRxPharma
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. QRxPharma Doses First Patients in Phase III Clinical Trial Program for its Dual Opioid Pain Therapy
2. QRxPharma Releases Successful Phase 3 Study Results for Dual Opioid Pain Therapy
3. QRxPharma Releases Additional Phase 3 Data for Q8003IR Dual Opioid Pain Therapy
4. QRxPharma Successfully Completes Comparative Study for Dual-Opioid(TM) Pain Therapy
5. QRxPharma Inks Deal with Patheon for the Manufacture of MoxDuo(TM)CR
6. QRxPharma Limited Announces A$21.6 Million Fully Underwritten Capital Raising
7. QRxPharma Initiates Second Pivotal Phase 3 Study of MoxDuo(TM)IR Dual-Opioid(TM) for NDA Submission
8. QRxPharma Limited and China Aoxing Pharmaceutical Company Announce Strategic Alliance for Development of MoxDuo(R)IV
9. QRxPharma Releases Additional Pivotal Phase 3 Combination Rule Study Data for MoxDuo(R)IR in Patients with Post-Surgical Pain
10. QRxPharma Successfully Completes Comparative Phase 1 Proof-of-Concept Study for MoxDuo(R) CR Tablet Formulation
11. QRxPharma Receives Positive Feedback from Scientific Advice Meetings in Europe on MoxDuo®IR Development and Registration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... PARIS , September 23, 2014 /PRNewswire/ ... tels que l,automobile, la santé, le ferroviaire ... en plus connectées, donneront progressivement accès à ... issues des nombreux capteurs installés au cœur ... estime à plusieurs dizaines de milliards le ...
(Date:9/23/2014)... Fla. and DUBLIN ... (OTC-BB: TNIB) ("we" or the "Company"), a biotechnology ... therapies for autoimmune diseases in emerging nations, today ... approved our common stock for DTC,s Deposit and ... Automated Securities Transfer Service ("FAST") transfer agent as ...
(Date:9/23/2014)... The Pennsylvania State Police will accept unwanted, expired ... of National Prescription Drug Take-Back Day. The service is ... Day is a national initiative, conducted in partnership with ... the public to dispose of expired, unused or unwanted ... From 10 a.m. to 2 p.m., unwanted ...
Breaking Medicine Technology:Altran transforme le big data du monde industriel en nouveau business 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 3TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 4
... needle-free vaccine,platform that elicits a robust immune response ... been awarded a U.S. patent. The University of,Michigan ... from the,university, licenses the patent and its associated ... nanoemulsion,technology, have elicited a dramatic immune response in ...
... Inc.,(Nasdaq: NUVO ) today announced that it ... 1 trial to determine the safety, tolerability and,pharmacokinetics ... approximately 30 healthy male volunteers., "This proof-of-concept ... to achieve rapid onset and offset of anticoagulation," ...
Cached Medicine Technology:New Patent Awarded for Antigen-Sparing Vaccines that Elicit Robust Immunity 2New Patent Awarded for Antigen-Sparing Vaccines that Elicit Robust Immunity 3Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172 2Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172 3
(Date:9/23/2014)... From first-hand experience, Matthew O'Farrell knows all ... it can be treated. , A medically retired Army ... His platoon sustained multiple attacks resulting in five casualties. ... combat-related PTSD and honorably discharged from the Army. , ... distanced myself from my friends and family,” recalled O’Farrell, ...
(Date:9/23/2014)... HealthDay Reporter TUESDAY, Sept. 23, 2014 ... for providing better care, not more ... choices. A new report suggests that,s the direction ... the IMS Institute for Healthcare Informatics in Parsippany, N.J., identifies ... the delivery of health care and use of medicines over ...
(Date:9/23/2014)... September 23, 2014 What information ... The National Quality Forum (NQF) released a report ... ), and an infographic ( http://bit.ly/1tX3lzA ) resulting ... of healthcare, how patients define affordability, and what ... get the best possible healthcare at the lowest ...
(Date:9/23/2014)... CORVALLIS, Ore. A recent Oregon survey about an ... into the daily routine of elementary school students found ... students and teachers, and offered clear advantages for overly ... was developed and produced by the Healthy Youth Program ... and is available nationally. , Brain Breaks leads children ...
(Date:9/23/2014)... 2014 Trevera provides multiple lines ... are Oracle Managed Services , Oracle Solutions ... versions of Oracle E-Business Databases and Applications, ... Trevera has announced a significant enhancement to its ... with their software technology management, project management, governance, ...
Breaking Medicine News(10 mins):Health News:Virtual Reality software to help treat PTSD 2Health News:Virtual Reality software to help treat PTSD 3Health News:Report Identifies Game Changers for U.S. Health Care 2Health News:Report Identifies Game Changers for U.S. Health Care 3Health News:Finding Affordable Care: Asking the Right Question is Key 2Health News:'Brain Breaks' increase activity, educational performance in elementary schools 2Health News:'Brain Breaks' increase activity, educational performance in elementary schools 3Health News:Trevera, Inc adds Management Support to Services 2Health News:Trevera, Inc adds Management Support to Services 3
... HealthDay Reporter , TUESDAY, Aug. 24 (HealthDay ... Monday,s decision by a U.S. judge to halt ... The temporary injunction, which basically blindsided the scientific ... the pre-2001 days. That was when then-President Bush ordered ...
... people lose weight and body fat when they exercise and eat ... (MR) spectroscopy can provide the answer and help predict who ... online and will appear in the November issue of the journal ... the same and have the same body mass index (BMI), but ...
... By Kathleen Doheny HealthDay Reporter , TUESDAY, Aug. ... sweetened, carbonated diet sodas a day boost a woman,s odds ... suggests such a link. The researchers looked at the ... a national study there from 1996 to 2002. The ...
... Aug. 24, 2010 The Joint Commission has ... a Primary Stroke Center, a distinction for hospitals fostering ... teams of neurologists, imaging specialists, nurses and technicians have ... limit damage during or after a stroke. Each year ...
... exams may increase a woman,s risk of developing radiation-induced ... in the October issue of Radiology . However, ... low. "A single breast-specific gamma imaging (BSGI) or ... of inducing fatal cancer greater than or comparable to ...
... success is surely sweeter than failure, it seems failure is ... flourish more in the long run, according to a ... the University of Colorado Denver Business School. Desai,s research, ... on companies and organizations that launch satellites, rockets and shuttles ...
Cached Medicine News:Health News:Scientists Dismayed by Stem Cell Research Ruling 2Health News:Scientists Dismayed by Stem Cell Research Ruling 3Health News:Fat distribution plays a role in weight loss success in patients at risk of diabetes 2Health News:Study Suggests Link Between Diet Sodas, Preterm Delivery 2Health News:Study Suggests Link Between Diet Sodas, Preterm Delivery 3Health News:UT Southwestern University Hospital -- St. Paul recognized as Primary Stroke Center 2Health News:UT Southwestern University Hospital -- St. Paul recognized as Primary Stroke Center 3Health News:New nuclear breast imaging technologies associated with higher cancer risks 2Health News:New nuclear breast imaging technologies associated with higher cancer risks 3Health News:University of Colorado Denver Business School study shows failure better teacher than success 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: