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QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten
Date:7/28/2014

ilfe blutbasierter therascreen Begleitdiagnostika zu überwachen. Mit höchst zuverlässigen genomischen Tests, denen Blutproben oder andere Körperflüssigkeiten zugrunde liegen und die für Ärzte und Patienten zusätzliche Möglichkeiten schaffen, die Behandlung zu bestimmen und die Krankheitsprogression zu überwachen, verändern wir die Therapielandschaft grundlegend", so Peer M. Schatz, Vorstandsvorsitzender von QIAGEN. "Das neue Projekt mit AstraZeneca, das auf unserem Rahmenvertrag basiert und eine von zahlreichen Partnerschaften mit Pharmaunternehmen darstellt, trägt zur Erweiterung unseres Portfolios zuverlässiger Begleitdiagnostika bei. Mit ihnen kreieren wir wertvolle Testinhalte für unsere Automationsplattformen der QIAsymphony-Produktfamilie. Die Kommerzialisierung entwickelter Tests wird durch das bestehende Netzwerk von Labors, die bereits mit dem branchenführenden Portfolio von QIAGEN für Begleitdiagnostika arbeiten, beschleunigt."

IRESSA ist ein Inhibitor der Tyrosinkinase des epidermalen Wachstumsfaktor-Rezeptors (EGFR-TK), der die Signale für das Wachstum und Überleben von Krebszellen blockiert. Bestimmte EGFR-Genmutationen treten bei einer signifikanten Anzahl von Lungenkrebserkrankungen auf. Diese mutationspositiven Tumore reagieren besonders sensitiv auf IRESSA. QIAGEN und AstraZeneca planen die Entwicklung eines Tests, der 21 EGFR-Mutationen erkennt und so Patienten ermittelt, bei denen eine große Wahrscheinlichkeit dafür besteht, dass sie von der Therapie profitieren. Dieser neue Test soll auf QIAGENs Technologie des von der FDA zugelassenen therascreen® EGFR RGQ PCR Kits basieren. Ausgeführt werden soll das neue Testkit auf dem Rotor-Gene Q-System von QIAGEN, das zu den Automationsplattformen der QIAsymphony-Produktfamilie gehört.

QIAGEN ist führend bei der Entwicklu
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