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QIAGEN und AstraZeneca entwickeln Begleittest auf Basis von Flüssigbiopsien zur erweiterten Bestimmung von EGFR-Mutationen bei Lungenkrebspatienten
Date:7/28/2014

GFR RGQ PCR Kit (therascreen EGFR Test) als gewebebasiertes Begleitdiagnostikum für Lungenkrebspatienten an, das im Juli 2013 in den USA von der FDA und im Mai 2014 in China zugelassen worden ist.

Die Partner arbeiten gemeinsam an der Entwicklung eines neuen Begleitdiagnostikums für IRESSA, das anstelle invasiver Verfahren zur Gewinnung von Gewebeproben flüssige Biopsieproben von NSCLC-Patienten nutzt. Daten mehrerer Studien, darunter die auf der "World Lung 2013"- Konferenz vorgestellte IFUM-Studie (IFUM = IRESSA Follow-up Measure), belegen die Möglichkeit, den EGFR-Status bei Patienten mit Lungenkrebs im fortgeschrittenen Stadium mit Hilfe von Blut-/Plasmaproben zu bestimmen. All jene Patienten, denen keine chirurgische Biopsie entnommen werden kann, können dank dieses Durchbruchs darauf hoffen, den Mutationsstatus mit Hilfe eines weniger invasiven Verfahrens bestimmen zu lassen.

Mondher Mahjoubi, Senior Vice President, Global Product & Portfolio Strategy bei AstraZeneca, sagte: "Die Verbindung aus AstraZenecas Expertise im Bereich Lungenkrebs mit den Fertigkeiten von QIAGEN auf dem Gebiet der Diagnostik verschafft uns die Möglichkeit, die Art und Weise, wie spezifische Tumorarten erkannt und behandelt werden, grundlegend zu verändern. Die Durchführung von Tests auf Basis zirkulierender Tumor-DNA wird es Ärzten erlauben, schnell und präzise auf die individuellen Bedürfnisse eines jeden Patienten einzugehen."

 "Wir freuen uns sehr, gemeinsam mit AstraZeneca an der Entwicklung dieser neuen Methode zu arbeiten, um das Leben für Patienten mit Lungenkrebs zu verbessern. Diese Zusammenarbeit erweitert QIAGENs schnell wachsendes Portfolio an Flüssigbiopsie-Lösungen für die personalisierte Medizin. Es bereitet den Weg dafür, den Krankheitsverlauf von Patienten künftig mith
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SOURCE Qiagen
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