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QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen
Date:7/24/2014

en, die unter dem Namen myelodisplastische Syndrome bekannt sind. Der SF3B1-Biomarker wurde in unser Genpanel GeneReadTM DNAseq Leukemia V2 für Next-Generation-Sequencing aufgenommen", erklärte Vincent Fert, Personalized Healthcare Program Leader bei QIAGEN. "Ausgehend von einem breitgefächerten Portfolio an molekularen Diagnostika für Blutkrebs wird QIAGEN auch weiterhin über Partnerschaften mit klinischen Forschern bei Pharmaunternehmen und akademischen Zentren daran arbeiten, den Nutzen der personalisierten Medizin auszuweiten. Da mehrere Pharmaunternehmen bereits potenzielle Krebsmedikamente entwickeln, die auf das SF3B1-Gen abzielen, birgt dieser Biomarker auch Potenzial für die Entwicklung eines Begleitdiagnostikums."

QIAGEN hat den SF3B1-Biomarker im Rahmen der fortschreitenden Erweiterung seines Onkohämatologieangebots für die klinische Forschung und Diagnostik einlizensiert. Drei weitere Spliceosom-Biomarker, die mit verschiedenen Blutkrebserkrankungen in Verbindung stehen, sowie Targeting-Varianten der Gene U2AF35 (U2AF1), ZRSR2 und SFRS2 sind ebenfalls Gegenstand der Lizenzvereinbarung. Sie alle sind Bestandteil des GeneReadTM DNAseq Leukemia V2 Genpanels für Next-Generation-Sequencing (NGS), das QIAGEN Anfang des Monats zusammen mit 13 weiteren neuen Krebs-Genpanels auf den Markt gebracht hat. Diese Krebspanels sind mit jedem NGS-Sequenziergerät kompatibel und lassen sich beliebig um andere Gene und Genregionen von biologischem Interesse erweitern.

Die GeneRead-Technologie bietet den kostengünstigsten und zeitsparendsten Ansatz für die Zielanreicherung von Testpanels für NGS. Die Panels erfordern lediglich 10 Nanogramm DNA-Ausgangsmaterial pro Pool, benötigen nur drei Stunden für die Zielanreicherung und verkürzen die Zeitspanne von der isolierten DNA-Probe bis hin zur sequenzierfähigen Bibliothek. Sie
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SOURCE QIAGEN N.V.
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