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QIAGEN and AstraZeneca Collaborate to Develop Liquid Biopsy-Based Companion Diagnostic to Advance EGFR Mutation Profiling in Lung Cancer Patients
Date:7/28/2014

HILDEN, Germany and LONDON, July 28, 2014 /PRNewswire/ --


  • Collaboration aims to create and commercialize companion diagnostic using genomic data from plasma samples to guide the use of IRESSA  for non-small cell lung cancer patients 
  • New blood test will build on QIAGEN's FDA-approved therascreen  EGFR test and is planned to run on Rotor-Gene Q, member of the QIAsymphony family of automated instruments 
  • Project enabled by AstraZeneca master framework agreement adds to QIAGEN's growing portfolio of liquid biopsy solutions, which  complement tissue-based testing solutions 

QIAGEN (NASDAQ: QGEN; Frankfurt, Prime Standard: QIA) today announced a collaboration agreement with AstraZeneca PLC (LSE, NYSE and OMX: AZN) for the co-development and commercialization of a liquid biopsy-based companion diagnostic to be paired with IRESSA, AstraZeneca's targeted therapy for non-small cell lung cancer (NSCLC). The project builds on a master framework agreement signed by both companies in 2013 and aims to develop and market a novel QIAGEN companion diagnostic that analyzes plasma samples to assess EGFR mutation status in NSCLC patients. The assay will be designed to guide the treatment of NSCLC patients with Astra Zeneca's oral monotherapy anti-cancer treatment when tumour tissue is not available. QIAGEN already offers the therascreen EGFR RGQ PCR Kit (therascreen EGFR test) as a tissue-based companion diagnostic for lung cancer patients, which was approved in the U.S. by the FDA in July 2013 and in China in May 2014.

The companies will collaborate to create a new companion diagnostic for IRESSA based on l
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SOURCE Qiagen
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