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Pulmonary Drug Delivery Systems: Technologies and Global Markets
Date:12/19/2011

elopment 62

TABLE 15 LIST OF METERED DOSE INHALERS AND INGREDIENTS 63

Fluticascone 63

Fluticasone and Salmeterol 64

Flunisolide 64

Beclomethasone 64

Transition to HFA propellants 65

Chlorofluorocarbons (CFCs) 65

TABLE 16 THE SEVEN CFC INHALERS 66

Analgesic Inhalers 66

Dry Powder Inhaler (DPI) 67

Dry Powder … (Continued) 68

TABLE 17 TYPES OF DPI DEVICES 69

Types of DPI Devices 69

TABLE 18 DPIS CURRENTLY ON THE MARKET 70

TABLE 18 (CONTINUED) 71

TABLE 19 DPI: ADVANTAGES VERSUS DISADVANTAGES 72

TABLE 20 TYPES OF DRY POWDER INHALERS (DPI) 72

DPIs for Children 72

Nebulizers 73

How Do They Work? 73

Use 74

TABLE 21 NEBULIZERS AND DRUGS 74

Use (Continued) 75

TABLE 22 NEBULIZERS: ADVANTAGES AND DISADVANTAGES 76

Ultrasonic Nebulizers 76

TABLE 23 VIBRATING MESH NEBULIZERS 77

Factors Influencing Clinical Effectiveness of Inhalation

Devices 78

CONCLUSIONS 79

CHAPTER FIVE: PULMONARY DRUG DELIVERY: DRUGS IN USE 80

CURRENT INHALATION DRUGS AND MARKET 80

AEROSOL AZTREONAM (CAYSTON) 80

DULERA (MOMETASONE FUROATE/FORMOTEROL

FUMARATE DIHYDRATE) 81

AMIKACIN 82

PULMONARY DELIVERY OF SYSTEMIC DRUGS 83

Antibiotics 83

Analgesics 83

Anti-emetics 83

TABLE 24 THERAPEUTIC AGENTS ADMINISTERED BY

INHALATION 84

Pulmonary Specific Vasodilators 84

Nicotine 85

Nebulizers for Pediatric Care 85

Vaccines 85

Obesity 85

Drugs and Inhalers: How do they Work? 85

TABLE 25 SHORT-ACTING BRONCHODILATOR INHALERS 86

TABLE 26 LONG-ACTING BRONCHODILATOR INHALERS 86

Steroid Inhalers 87

TABLE 27 INHALED STEROID MEDICATIONS 87

TABLE 28 COMBINATION INHALERS 87

Breath-Activated Inhalers 88

Nebulizers 88

Pulmonary Delivery 89

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