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Published Results Show Denosumab Superior to Zometa® in Delaying or Preventing Bone Complications in Patients With Bone Metastases From Advanced Breast Cancer
Date:11/8/2010

ating SREs.(ii) (iii) (iv)  Events considered to be SREs include fractures, spinal cord compression, and severe bone pain that may require surgery or radiation. (v) Such events can profoundly disrupt a patient's life and can cause disability, pain or even death. (vi) (vii) (viii)

Patients who experience an SRE as a result of bone metastases incur significantly higher medical costs compared with those who do not experience such events. (ix) (x) (xi) Studies have shown that the costs of treating a SRE are significant. (x) (xii) In fact, the total economic burden of patients with bone metastases in the U.S. alone is estimated to be $12.6 billion annually.(xiii)

About Denosumab and Amgen's Research in Bone BiologyDenosumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). The denosumab development program is the largest ever initiated by Amgen. This broad and deep development program demonstrates Amgen's commitment to researching and delivering pioneering medicines to patients with unmet medical needs. Amgen is studying denosumab in numerous tumor types across the spectrum of cancer-related bone diseases. Over 11,000 patients have been enrolled in the denosumab oncology clinical trials, testing the drug for the reduction of SREs in patients with breast and prostate cancer, as well as other solid tumors and multiple myeloma, for the amelioration of treatment-induced bone loss in patients with non-metastatic breast or prostate cancers, and for its potential to delay bone metastases in prostate and breast cancers.

About AmgenAmgen discovers, develops, manufactures and delivers innovative human therapeutics.  A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to pa
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