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Publication by KaloBios and Collaborators Shows EphA3 as Target for Highly Selective Anticancer Therapy
Date:8/14/2014

monstrated that treatment of human tumor xenografts with a highly specific anti-EphA3 monoclonal antibody can effectively kill tumor-resident mesenchymal/stromal stem cells and inhibit tumor growth by disrupting the architecture and function of the tumor microenvironment."

"These data add to the rationale for our current clinical program using  anti-EphA3  to treat leukemias and represent a clear rationale for the potential expansion of our investigation of KB004, KaloBios' Humaneered® anti-EphA3 mAb,  into solid tumor indications," said Geoffrey Yarranton, Ph.D., KaloBios' chief scientific officer and executive vice president of research and development.  KaloBios is currently conducting a Phase 1/2 clinical trial of KB004 in hematologic malignancies, with the Phase 2 expansion portion of that trial focused on acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myelofibrosis (MF) patients with EphA3-positive malignancies.

"Research points to stromal cells playing a key role in chemoresistance, protecting tumors from the killing effects of many anticancer drugs. Thus, if KB004 is able to kill these cells protecting either solid tumors or tumors in the bone marrow,  it might offer a particular powerful new way to fight such cancers," Dr. Yarranton noted.

About KaloBios

KaloBios Pharmaceuticals, Inc. is developing a portfolio of proprietary, patient-targeted, first-in-class monoclonal antibodies designed to treat severe life-threatening or debilitating diseases for which there is an unmet medical need, with a clinical focus on severe respiratory diseases and cancer.

Currently, KaloBios has advanced three programs to clinical development:

  • KB001-A is an anti-PcrV mAb fragment being developed for the prevention and treatment of Pseudomonas aeruginosa (Pa) infection. KaloBios is conducting a 180
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SOURCE KaloBios Pharmaceuticals, Inc.
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