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Publication by KaloBios and Collaborators Shows EphA3 as Target for Highly Selective Anticancer Therapy
Date:8/14/2014

SOUTH SAN FRANCISCO, Calif., Aug. 14, 2014 /PRNewswire/ -- KaloBios Pharmaceuticals, Inc. (Nasdaq: KBIO) today announced the publication of preclinical findings describing EphA3 as a novel target expressed by a broad range of human tumors,  and whose activation can lead to the selective disruption of the tumor microenvironment and newly formed tumor blood vessels. The expression and function of EphA3 in the tumor microenvironment but not in adult normal tissues together with the favorable safety profile as observed thus far in a Phase 1-2 clinical study, where infusion reactions have been the most common adverse event, supports the development of KB004 (KaloBios' Humaneered® anti-EphA3 monoclonal antibody [mAb]) as a potential treatment for both hematologic and solid tumors.

The new research findings, published online this week by the journal of the American Association for Cancer Research, are described by scientists from Monash University School of Biomedical Sciences and Ludwig Institute for Cancer Research in Melbourne, Australia, and KaloBios.

"Eph receptors constitute the largest family of receptor tyrosine kinases, and EphA3 is important in human fetal development.  EphA3 is also found in the mesenchymal tissues of various developing organs but is virtually undetectable in normal adult tissues," said Professor Andrew Scott, from the Ludwig Institute for Cancer Research. "However, EphA3 is over-expressed in many solid and hematologic tumors where it is implicated in cell positioning and possible tumor stem cell survival."

He continued, "In this publication, we show that EphA3 is prominently expressed and functional in the tumor microenvironment, where it contributes to the formation of new blood vessels, and is also found on stromal tissue. We have also de
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SOURCE KaloBios Pharmaceuticals, Inc.
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