Navigation Links
Proteolix to Present Clinical and Preclinical Data at the 50th Annual Meeting of the American Society of Hematology

SOUTH SAN FRANCISCO, Calif., Nov. 25 /PRNewswire/ -- Proteolix, Inc., a leader in the discovery and development of novel therapeutics that target protein degradation pathways in cancer and autoimmune diseases, today announced that data from two ongoing Phase 2 clinical trials of carfilzomib in multiple myeloma will be presented at the upcoming 50th Annual Meeting of the American Society of Hematology (ASH). Carfilzomib is the first in a new class of specific proteasome inhibitors and is currently in multiple clinical trials for hematologic malignancies and solid tumors. This year's ASH conference will be held December 6-9, 2008 at the George Moscone Center in San Francisco, California.

Sundar Jagannath, M.D., Chief of the Multiple Myeloma Program, Bone Marrow and Blood Stem Cell Transplantation at St. Vincent's Comprehensive Cancer Center in New York will present initial results from Proteolix's Phase 2 study of carfilzomib for the treatment of patients with relapsed and refractory multiple myeloma during the Novel Therapies for Myeloma and Related Disorders session at 7:00 a.m. on Tuesday, December 9, 2008. This ongoing Phase 2 trial is an open-label multi-center study of single-agent carfilzomib in patients who have previously failed at least two prior treatments, containing bortezomib and either lenalidomide or thalidomide, and are refractory to their last treatment. Data from a second ongoing Phase 2 clinical trial of single-agent carfilzomib in relapsed multiple myeloma patients (stratified by prior therapy with bortezomib) will be presented immediately thereafter at 7:15 a.m. by Ravi Vij, M.D., Associate Professor of Medicine, Division of Oncology, Section of Bone Marrow Transplantation, Washington University School of Medicine.

In addition to the oral presentations, the company will have several poster presentations highlighting the results of preclinical studies that further characterize the mechanism and safety profile of carfilzomib. Proteolix will also have a poster presentation on the preclinical pharmacology and characterization of its oral proteasome inhibitor known as PR-047.

A complete list of the company's oral and poster presentations at the ASH meeting follows:

    Oral Presentations -- Tuesday, December 9, 2008
      Session:  Novel Therapies for Myeloma and Related Disorders
      --  7:00 a.m. PST: Initial Results of PX-171-003, An Open-Label,
          Single-Arm, Phase II Study of Carfilzomib (CFZ) in Patients with
          Relapsed and Refractory Multiple Myeloma (MM) (Abstract #864)
      --  7:15 a.m. PST: Initial Results of PX-171-004, An Open-Label,
          Single-Arm, Phase II Study of Carfilzomib (CFZ) in Patients with
          Relapsed Myeloma (MM) (Abstract #865)
      Location: Moscone Center, Gateway Ballroom 103-South

    Poster Presentations
    Sunday, December 7, 2008, 6:00 p.m. -- 8:00 p.m. PST
      Session: Molecular Pharmacology, Drug Resistance Poster II
      --  Non-Proteasomal Targets of Proteasome Inhibitors Bortezomib and
          Carfilzomib (Abstract #2657)
      Session: Myeloma -- Pathophysiology and Preclinical Studies Excluding
       Therapy Poster II
      --  The Selective Proteasome Inhibitor Carfilzomib is Well Tolerated in
          Experimental Animals with Dose Intensive Administration (Abstract
      Location: Moscone Center Hall A

    Monday, December 8, 2008, 5:30 p.m. -- 7:30 p.m. PST
      Session: Myeloma -- Pathophysiology and Preclinical Studies Excluding
       Therapy Poster III
      --  Induction of Sustained Early G1 Arrest by Selective Inhibition of
          CDK4 and CDK6 Primes Myeloma Cells for Synergistic Killing by
          Proteasome Inhibitors Carfilzomib and PR-047 (Abstract #3670)
      --  Preclinical Pharmacology and in vitro Characterization of PR-047, An
          Oral Inhibitor of the 20S Proteasome (Abstract #3671)
      Location: Moscone Center Hall A

About Proteolix

Proteolix, Inc. is a privately-held biopharmaceutical company, headquartered in South San Francisco, dedicated to discovering, developing and commercializing novel therapeutics that target protein degradation pathways for cancer and autoimmune diseases. Proteolix's lead product, carfilzomib (PR-171), the first in a new class of highly specific proteasome inhibitors, is currently in multiple Phase 2 clinical studies to evaluate its safety and efficacy in hematologic and solid tumor malignancies. Proteolix is also developing a pipeline of novel proteasome inhibitors, including an oral proteasome inhibitor and a selective immunoproteasome inhibitor. For additional information on Proteolix, please visit

     Contact information
     Investors:                      Media Inquiries:
     Matthew Ferguson                BCC Partners
     Chief Financial Officer         Karen L. Bergman or Michelle Corral
     650-266-2825                    650-575-1509 or 415-794-8662

SOURCE Proteolix, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
2. Proteolix Initiates Multicenter Open-label Study of the Safety and Activity of Carfilzomib in Subjects With Relapsed Solid Tumors
3. Proteolix Initiates Phase 2 Clinical Trial of Carfilzomib in Patients With Relapsed Solid Tumors
4. Proteolix Initiates Phase 1b Clinical Trial of Carfilzomib in a Combination Regimen for Patients With Relapsed Multiple Myeloma
5. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
6. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
7. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
8. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
9. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
10. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
11. Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference
Post Your Comments:
(Date:10/12/2017)... 12, 2017   Divoti USA will engrave ... the standard of the latest FDA requirements, which stipulates new criteria ... Anyone in need of Medical ID jewelry such as Medical ID ... are engraved in terms of the new FDA requirements . ... Divoti offers this dark mark ...
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
Breaking Medicine News(10 mins):