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Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting
Date:6/1/2009

Carfilzomib Achieves 26 Percent Clinical Benefit Response Rate in Phase 2 Trial of Relapsed and Refractory Multiple Myeloma Patients - Proteolix Expands Trial

ORLANDO, Fla. and SOUTH SAN FRANCISCO, Calif., June 1 /PRNewswire/ -- Proteolix, Inc. today presented results from the company's most advanced clinical trial of single-agent carfilzomib demonstrating anti-cancer activity and progression-free survival in patients with relapsed and refractory multiple myeloma. Carfilzomib is the first in a new class of selective, irreversible proteasome inhibitors being developed by Proteolix for the treatment of hematologic malignancies and solid tumors.

Data from the Phase 2 clinical trial of relapsed and refractory multiple myeloma patients were presented today in an oral session by Sundar Jagannath, M.D., Chief of the Multiple Myeloma Program, Bone Marrow and Blood Stem Cell Transplantation at St. Vincent's Comprehensive Cancer Center in New York, at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO). In addition, Proteolix presented positive data today from an ongoing Phase 2 clinical trial of single-agent carfilzomib in relapsed multiple myeloma patients and from a Phase 1b clinical trial of carfilzomib in combination with lenalidomide and dexamethasone during the "Lymphoma and Plasma Cell Disorders" poster session.

"In spite of advances in the treatment of multiple myeloma, new selective agents are needed for patients who have failed other available therapies," said Dr. Jagannath. "Carfilzomib is well tolerated and demonstrates clear single-agent activity in a heavily pre-treated multiple myeloma patient population. Patients enrolled in this Phase 2 trial lack treatment alternatives, having failed prior treatment with all approved agents and stem cell transplant."

Sustained Clinical Benefit in Relapsed and Refractory Patients

The Phase 2 clinical trial
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1. Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting
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3. Proteolix Initiates Phase 1b Clinical Trial of Carfilzomib in a Combination Regimen for Patients With Relapsed Multiple Myeloma
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