Navigation Links
Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting
Date:5/30/2009

Promising Anti-cancer Activity Observed in Relapsed Patients

ORLANDO, Fla., and SOUTH SAN FRANCISCO, Calif. , May 30 /PRNewswire/ -- Proteolix, Inc. today reported on clinical advances for its carfilzomib solid tumor program in an oral presentation at the 2009 Annual Meeting of the American Society of Oncology (ASCO) in Orlando, Florida. Data from a Phase 1b study and an ongoing Phase 2 clinical trial of carfilzomib in relapsed patients with advanced solid tumors demonstrate promising single-agent anti-cancer activity. Carfilzomib is the first in a new class of selective, irreversible proteasome inhibitors being developed by Proteolix for the treatment of hematologic malignancies and solid tumors.

"In these clinical studies, carfilzomib demonstrated promising activity as a highly selective and potent inhibitor of the proteasome for treatment of solid tumor patients. The compound's unique characteristics enable the drug to be well tolerated with consecutive day dosing, which in turn appears to improve anti-cancer activity. Early results among patients with late-stage or metastatic solid tumors who have failed multiple prior treatments are encouraging, with a number of patients achieving stable disease or better lasting for several months," said Peter J. Rosen, M.D., Medical Director of the Tower Cancer Research Foundation and Emeritus Professor, UCLA.

Data from the Phase 1b/2 clinical trials of relapsed solid tumor patients were presented by Dr. Rosen at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) in an oral presentation titled "Phase II results of Study PX-171-007: A Phase Ib/II study of carfilzomib (CFZ), a selective proteasome inhibitor, in patients with selected advanced metastatic solid tumors" (Abstract #3515).

The Phase 1b dose-escalating clinical trial enrolled patients with a variety of relapsed solid tumors established a dosing schedul
'/>"/>

SOURCE Proteolix, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Proteolix to Present Clinical and Preclinical Data at the 50th Annual Meeting of the American Society of Hematology
2. Proteolix Initiates Phase 1b Clinical Trial of Carfilzomib in a Combination Regimen for Patients With Relapsed Multiple Myeloma
3. Proteolix Initiates Phase 2 Clinical Trial of Carfilzomib in Patients With Relapsed Solid Tumors
4. Proteolix Initiates Multicenter Open-label Study of the Safety and Activity of Carfilzomib in Subjects With Relapsed Solid Tumors
5. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
6. Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection
7. TYRX Presents Early Clinical Results from AIGISRX(TM) Antibacterial Envelope Retrospective Registry
8. Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting
9. MedImmune Presents New Data Demonstrating Increased Risk for Medically Attended RSV in Late-Preterm Infants
10. Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia
11. Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... Conn. , Oct. 17, 2014 UBM Medica ... a leading online community and information resource for neurologists ... disease and Alzheimer disease , with discussions of ... to 1 million Americans have Parkinson disease , more ... dystrophy, or Lou Gehrig disease. Diagnosis can be ...
(Date:10/17/2014)... 2014 ... has announced the addition of the  ... Automated External Defibrillators (AED) Market"  report ... ,The report North American Automated External ... of devices based upon following sub-segments ...
(Date:10/17/2014)... 17, 2014  Talyst, a market leader in pharmacy ... Meeting in Nashville, TN. The ... leading solution for onsite, remote medication dispensing. ... to safely and securely dispense medication onsite, on demand. ... helps ensure that the correct medication gets to the ...
Breaking Medicine Technology:Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3Micro Market Monitor : North American Automated External Defibrillators (AED) Market 2Talyst Exhibits at LeadingAge Annual Meeting 2
... 16 Triage Wireless(TM), Inc., a medical device company ... today announced it has changed its corporate name to ... change the Company,s name arose from a settlement with ... under the Triage brand. Inverness obtained the Triage ...
... RARITAN, N.J., Nov. 16 Epilepsy and seizures affect nearly 3 ... cases, no cause is apparent. Those who live daily with the ... occur, how long it will last or where they will be, ... the condition. The wonder behind the diagnosis, the perseverance in ...
Cached Medicine Technology:National Expressions of Courage Art Contest Unveils Stories of Inspiration 2National Expressions of Courage Art Contest Unveils Stories of Inspiration 3National Expressions of Courage Art Contest Unveils Stories of Inspiration 4National Expressions of Courage Art Contest Unveils Stories of Inspiration 5
(Date:10/20/2014)... 20, 2014 Succeed is proud to announce ... who participated in the Every Body Walk! campaign ... awareness project that encourages workers to be more active outside ... Program, which concluded at the end of September, was a ... and metro areas. Participating companies gave their staff pedometers ...
(Date:10/20/2014)... 20, 2014 It’s hard to imagine what ... and vulnerable children around the world, it’s a reality. And ... many children are forced to walk barefoot on rocky terrain ... or play with their friends. , Buckner International's ... Air1 Radio in October to encourage support for Air1 ...
(Date:10/19/2014)... October 20, 2014 The leading ... ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the best ... platforms for those who want to buy high ... time. , The IT manager of Top10BestSEOHosting.com says, ... most recommended suppliers for everyone. A lot of ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest ... and HostMonster are the best VPS hosting suppliers ... is the method of partitioning a physical server ... the appearance and capabilities of running on someone’s ... pays close attention to VPS products and related ...
(Date:10/19/2014)... -- New stem cell-based research could improve understanding of ... new study suggests. Scientists used stem cells to ... lab dish. They then transplanted the organoids into mice, ... to the researchers. "This provides a new way ... cause intestinal failure, from genetic disorders appearing at birth ...
Breaking Medicine News(10 mins):Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Scientists Grow, Implant Human Intestinal Tissue in Mice 2
... International, a leading,Clinical Research Organization, has announced a ... Planning. The partnership between PRA,Taiwan (the Taiwanese ... joint management of multinational clinical trials in Asia ... and data management. , ...
... Joint Commission,s OPPE and FPPE standardsPORTLAND, Ore., Jan. ... new services to help hospitals and ambulatory surgical ... their physicians, as well as meet accreditation standards. ... professional practice evaluation (OPPE) and focused professional practice ...
... Opportunities to Reverse Tobacco Caused Public Health CrisisEditor,s ... available at: www.stateoftobaccocontrol.org . WASHINGTON, Jan. 13 ... State of Tobacco Control 2008 report today, ... strength of state and federal laws to protect ...
... Designer Michael Kors, Will Take Place at Bal Harbour Shops ... to Cure Paralysis is proud to announce that multi-platinum ... be the musical headliner at Destination Fashion 2009 ... Pointer Sisters will also perform. American designer and ...
... Diagnostics Market with a Canine Heartworm Antigen Rapid Test ... ABAX ), a medical products company manufacturing ... veterinary markets, announced today that it has signed an ... Canine Heartworm Lateral Flow / Rapid Test Kit.This manufacturing ...
... doctors and human rights advocates convened by Physicians ... assessment of Zimbabwe,s health crisis has found the ... health care system threatens the people of Zimbabwe ... the widely reported cholera epidemic, the report highlights ...
Cached Medicine News:Health News:PRA Expands Capabilities to Execute Multinational Trials in Asia 2Health News:AllMed Announces PeerScore Solutions for Hospital Peer Review 2Health News:AllMed Announces PeerScore Solutions for Hospital Peer Review 3Health News:American Lung Association Report Card Flunks Federal Government and Most States for Neglecting to Prevent Tobacco Caused Illness 2Health News:American Lung Association Report Card Flunks Federal Government and Most States for Neglecting to Prevent Tobacco Caused Illness 3Health News:American Lung Association Report Card Flunks Federal Government and Most States for Neglecting to Prevent Tobacco Caused Illness 4Health News:Multi-Platinum Recording Artist Seal Announced as Headliner for Destination Fashion 2009 Benefiting The Buoniconti Fund to Cure Paralysis 2Health News:ABAXIS Announces Contract Manufacturing Agreement with SA Scientific, Ltd. 2Health News:ABAXIS Announces Contract Manufacturing Agreement with SA Scientific, Ltd. 3Health News:Health System Collapse Requires International Intervention, Concludes PHR Report 2Health News:Health System Collapse Requires International Intervention, Concludes PHR Report 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: