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Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome
Date:6/15/2009

her inflammatory and autoimmune diseases," said John A. Scarlett, M.D., President and Chief Executive Officer of Proteolix. "Proteolix has now discovered and developed carfilzomib, a proteasome inhibitor in late Phase 2 clinical trials for the treatment of multiple myeloma, PR-047 as an oral proteasome inhibitor also targeted in oncology, and now PR-957 as a strong drug candidate for the treatment of autoimmune disorders. This demonstrates the Company's unique discovery and development capabilities, as well as its leadership in the field of proteasome inhibition."

About Proteolix

Founded in December 2003, Proteolix, Inc. is a privately-held biotechnology company, headquartered in South San Francisco, dedicated to discovering, developing and commercializing novel therapeutics that target protein degradation pathways for cancer and autoimmune diseases. Proteolix's lead product, carfilzomib, is the first in a new class of selective, irreversible proteasome inhibitors. Proteolix is also developing a pipeline of novel proteasome inhibitors, including a selective, oral proteasome inhibitor and a selective immunoproteasome inhibitor. For additional information on Proteolix, please visit www.proteolix.com.

    Contact information
    Media Inquiries:                       All Other Inquiries:
    BCC Partners                           Craig C. Parker
    Karen L. Bergman or Michelle Corral    Senior Vice President, Finance and
    650-575-1509 or 415-794-8662           Corporate Development & Chief
                                           Financial Officer
                                           650-266-2825


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SOURCE Proteolix, Inc.
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