Navigation Links
Protein Tomography(TM) Reveals Molecular Mode of Action of Humax-EGFr Published in PNAS
Date:4/22/2008

STOCKHOLM, April 22 /PRNewswire/ --

- Summary: Using Protein Tomography(TM), Sidec Investigated in Collaboration With Genmab the Molecular Mode of Action of Humax- EGFr (Zalutumumab). In This Study Sidec Showed That EGFr is Flexible and That Zalutumumab Locks the EGFr Into a Very Compact Inactive Conformation Thereby Inhibiting Cell Signaling and Cancer Cell Growth.

Sidec AB announced today that together with Genmab the molecular mode of action of HuMax-EGFr (zalutumumab) has been determined. It was shown that zalutumumab locks the epidermal growth factor receptor (EGFr) molecules into a compact, inactive conformation. Flexibility is crucial to the role of the EGFr in signaling, and this study, done with Sidec's proprietary methodology Protein Tomography(TM), has played a central role in the understanding of the inhibition of individual EGFr molecules. Moreover, Sidec's unique technology confirmed that HuMax-EGFr binds bivalently to the EGFr. Prevention of the receptor dimerization as well as locking the EGFr molecules in the inactive form both contribute to the inhibition of signaling and cancer cell growth.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080220/294289 )

This data will be demonstrated on Sidec's First Protein Tomography Symposium at the fourth annual PEGS Summit 28 April - 2 May at the Intercontinental Hotel in Boston.

With Protein Tomography it is possible to study the molecular mode of action of individual molecules in situ and in vitro. The unique biological information obtained can also be used to prioritize the most promising monoclonal antibodies/projects and to locate the antibody binding epitope.

"These results clearly show the importance of understanding the molecular mode of action and to capture the flexibility of a receptor when developing therapeutic antibodies. Today this can only be done with Protein Tomograph
'/>"/>

SOURCE Sidec AB
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Nostrum Announces the Successful Completion of Early Proof-of-Concept Study for its Novel Clot Busting Therapeutic Protein
2. Arriva Pharmaceuticals Moves Forward to Phase 2b Development of Lead Inhaled Protein rAAT Replacement Therapy for Hereditary Emphysema
3. NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference
4. Fundamental Applied Biology, Inc. Is Awarded SBIR Phase IIB Grant for the Commercialization of Protein Therapeutics Using Cell Free Technology
5. Neptune Industries Reports Favorable Phase II Trial Results on Ento- Protein(TM)
6. VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor
7. The New England Journal of Medicine Publishes First Clinical Results for MedImmunes Chitinase-like Protein YKL-40 in Patients With Asthma
8. First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs
9. Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy
10. Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant
11. Study Suggests Soy Protein May Reduce Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... CHAPEL HILL, N.C. , Dec. 19, 2014 ... how to optimize a product,s web presence to ... critical. Brand websites, in particular, must meet the ... in regulations and culture. According ... LLC, more than half of the participating companies ...
(Date:12/19/2014)... FORT WORTH, Texas , December 18, 2014 ... is a networked software application/module that is used ... and related images. RIS comprises a patient tracking ... tracking system. The integration of RIS with HIS ... is used for patient registration and patient scheduling, ...
(Date:12/19/2014)... Mass. , Dec. 18, 2014  Decision Resources ... the United States will increase to ... will be primarily driven by expansion in the large ... energy devices will be increasingly adopted due to the ... Other key findings from Decision Resources Group,s ...
Breaking Medicine Technology:Building a Best-in-Class Pharma Global Brand Website 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3
(Date:12/21/2014)... 2014 SCI explores disability ... and systemic barriers for disabled athletes with Aaron ... has a condition called juvenile macular degeneration, where he ... he adapted his athletic ambitions to his vision and ... triathlon to pioneer the way for other blind and ...
(Date:12/21/2014)... 21, 2014 Concept Plus, LLC. a ... headquartered in Fairfax, VA., today announced it has been ... 50 list, which ranks the fastest growing government contracting small ... to 2013. , This is the first year that Concept ... # 20 with a 95.92% compound annual growth rate. “For ...
(Date:12/20/2014)... NY (PRWEB) December 20, 2014 An ... healthcare sector have benefited the Massage Services ... discretionary characteristics of industry products, the anticipated 1.0% annualized ... period has provided consumers with the means to afford ... have received a massage in a given year has ...
(Date:12/20/2014)... Recently, VogueQueen.com, a leading wedding dress wholesaler and ... for 2015. Great discounts are now offered on ... can get a discount, up to 80% off, when ... January 30, 2015. , VogueQueen.com has recently released its ... dress promotion. Many customers worldwide like VogueQueen’s special designs ...
(Date:12/20/2014)... The aftermath of the November 24th hack ... only in Hollywood, but worldwide. As reported in ... of that attack are starting a finger-pointing game which could ... But they are not the only ones affected, regular employees ... some embarrassing times ahead, agents and lawyers could be in ...
Breaking Medicine News(10 mins):Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 3Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5
... Health Plans Move Closer to Cutting AmerisourceBergen-Brand,Pharmacies ... WASHINGTON, Feb. 28 AmerisourceBergen (NYSE:,ABC) warehouse ... hundreds of,their fellow Teamsters outside ABC,s annual ... a warning to investors about,ongoing and illegal ...
... Standardized ... Digital RSA Solution, ... IDL), the global leader in digital radiography (DR) for image,quality ... as the DR component for an imaging product suite currently,under ...
... study from the American Cancer Society finds that while breast ... U.S. state, for African American women, death rates are either ... study, published early online in the journal Cancer Causes and ... are decreasing in only 11 of 37 states with sufficient ...
... Dental Experts to Advance ... of CCLAD in Dentistry, LIVINGSTON, N.J., Feb. 28 ... leader in,advanced injection technologies, today reported that earlier this ... (CCLAD) Summit in New Orleans. The Summit welcomed a ...
... to unprotected, masochistic sex as adults , , THURSDAY, Feb. ... consequence of spanking: risky sexual behaviors, or even sexual ... one more harmful side effect to spanking," said Murray ... the findings of four studies at the American Psychological ...
... on March 17, 2008 at 10:00 a.m., FREEHOLD, ... NAHC ) will report financial results,for the fourth ... March,17, 2008 prior to market open., The Company ... March,17, 2008 at 10:00 a.m. Eastern Time (ET). Following ...
Cached Medicine News:Health News:Teamsters Warn of Possible Work Stoppages, Service Disruptions at AmerisourceBergen 2Health News:IDC X-Series DR system selected for use in leading edge RSA clinical trial application 2Health News:IDC X-Series DR system selected for use in leading edge RSA clinical trial application 3Health News:Breast cancer death rates among black women not decreasing across all states 2Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 2Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 3Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 4Health News:Milestone Scientific Hosts First International Computer-Controlled Local Anesthetic Delivery (CCLAD) Summit 5Health News:Spanking Raises Chances of Risky, Deviant Sexual Behavior 2Health News:Spanking Raises Chances of Risky, Deviant Sexual Behavior 3Health News:National Atlantic Holdings Corporation to Report Fourth Quarter and Year-End 2007 Earnings on March 17, 2008 2Health News:National Atlantic Holdings Corporation to Report Fourth Quarter and Year-End 2007 Earnings on March 17, 2008 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: