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Protein Shown to Play a Key Role in Normal Development of Nervous System
Date:10/8/2008

es, given the proper stimulation. If we can eventually manipulate this protein's activity in neurons, we might enhance communication among those neurons, and allow patients to receiver greater benefit from therapeutic exercises."

The second study by Kalb and colleagues, published Oct. 8, described the molecular pathways by which GluR1 binds with another protein, SAP97, to control dendrite growth during the early postnatal period. "Our work suggests that GluR1 brings the scaffolding protein SAP97 to the membrane of nerve cells, where it can receive pro-growth signals to build dendrites."

Although both studies were performed in mice, the neurodevelopmental process is considered to be similar for all mammals. "The first few weeks of postnatal life are a critical period for sculpting the architecture of the nervous system," added Kalb. "Greater understanding of how neural architecture develops normally may give us insight into how to intervene when things go wrong."

Both studies received grant support from the U.S. Public Health Service, part of the National Institutes of Health. The Pennsylvania Department of Health also provided funding. Dr. Kalb's co-authors included collaborators from the United States (from The Children's Hospital of Philadelphia, Johns Hopkins University and the State University of New York, Buffalo) and abroad, in Germany and Japan.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and pub
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SOURCE The Children's Hospital of Philadelphia
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