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Promise of Vical's CMV Vaccine Noted by Independent Experts
Date:6/5/2008

l drug use and viral load in patients receiving vaccine compared with patients receiving placebo. Other important evaluations will include measurement of specific immune responses against CMV targeted by the vaccine.

"We are advancing well toward completion of enrollment in our Phase 2 CMV vaccine trial," said Ronald B. Moss, M.D., Vice President of Clinical Development at Vical, "and are on track for our planned interim evaluation of safety and efficacy data in the second half of 2008. Our immunotherapeutic vaccine may help address the serious healthcare problem of CMV reactivation for transplant patients, and could eventually be useful in preventing birth defects caused by CMV infection of pregnant women."

About CMV

CMV is a herpes virus that infects more than half of all adults in the United States by age 40, and is even more widespread in developing countries. While a healthy immune system typically protects an infected person against CMV disease, it rarely succeeds in completely eliminating the infection, and those whose immune systems are not fully functional are at high risk of CMV proliferation, potentially leading to severe illness or death. These include transplant patients who take immunosuppressive drugs, and fetuses and newborns of mothers who first become infected during pregnancy.

CMV infection affects 30 to 60 percent of the patients undergoing various transplant procedures, causing transplant rejection, serious illness and even death if untreated. Expensive antiviral drug therapy is used to control the disease, but does not eliminate the infection. Congenital CMV infection affects one out of every hundred infants, and causes severe consequences in about 3,600 infants and death in about 400 each year in the United States.

There is no approved vaccine against CMV. Vaccine approaches that result in predominantly antibody responses to CMV have not proven highly effective in transplant patients. Vaccine approaches using
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SOURCE Vical Incorporated
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