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Prometheus and the Medco Research Institute® to Evaluate the Use of Prometheus' Thiopurine Metabolite Testing for Optimizing Treatment of Inflammatory Bowel Disease Patients
Date:8/15/2011

ing thiopurine drugs."

"Programs of this nature have the potential to show that understanding a patient's molecular make-up with the help of a diagnostic test can improve a drug's efficacy and safety," said Felix Frueh, PhD, President, Medco Research Institute.  "Working with Prometheus, Medco can help its clients better understand the value of these tests for IBD patients, and may assist physicians to make a personalized treatment decision for patients with this serious disease."

Through this collaboration, the companies will conduct the RECEIPT project (Research to Evaluate the Cost Effectiveness of Interventions with Prescriptions of Thiopurines), a pilot program to evaluate the benefit of PTM testing in IBD patients who have recently received a prescription for either 6MP or Aza.  In addition, the collaboration will evaluate the cost effectiveness of PTM testing.

The Medco Research Institute will work with Medco clients to recruit patients to take part in the pilot program.  It is anticipated that up to 500 Medco members who are using 6MP or Aza will have the PTM testing performed, and the downstream medical and pharmacy data from these patients will be compared to a similar number of Medco members who did not received PTM testing as part of their care, in order to determine the impact of PTM testing.

Personalized medicine is an area of healthcare that is becoming more widely used to focus on how a person's molecular makeup can affect their ability to respond to medications, allowing physicians better precision in selection or dosing of a drug thereby improving drug safety and efficacy.

About IBD

IBD, including Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the intestinal tract. Symptoms of the disease may include diarrhea, abdominal pain, fever and rectal bleeding. Patients may require long-term medical care, including hospitalizations, surgeries and therapeutics. T
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