Navigation Links
Prometheus Announces New Method for Real-Time Monitoring of Patients Treated With Biologic Therapy
Date:5/13/2010

SAN DIEGO, May 13 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced a new method for detecting antibody levels in individual patients treated with infliximab, a biologic therapy that has been used to treat more than a million patients across a number of autoimmune diseases, including rheumatoid arthritis, Crohn's disease and ulcerative colitis.

Human anti-chimeric antibody (HACA) levels have been associated with decreased duration of response and increased side effects in infliximab-treated patients (1). Current methods for detecting HACA are limited by the presence of infliximab and therefore require a minimum of 8 weeks following therapy for accurate measurement. To overcome these limitations, Prometheus has developed a proprietary highly sensitive method to measure HACA and infliximab levels in patient serum in real time. The Company believes this method can also be applied to detect other biologic drugs and their antibodies.

"Early and accurate detection of antibody levels during the course of biologic therapy may enhance our ability to assess reasons for loss of response," said David Rubin, M.D., Associate Professor of Medicine, Co-Director, University of Chicago Inflammatory Bowel Disease Center. "In addition, we anticipate that therapeutic monitoring of biologic therapy may become routine in our approach to individualizing therapies to maximize effectiveness and minimize adverse events."

Data from a preliminary study of this novel method for early detection of HACA during infliximab treatment were recently presented by Prometheus scientists at Digestive Disease Week (DDW), the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. The presentation, entitled "Measurement of Human Anti-Chimeric Antibodies (HACA) and Infliximab Levels in Patient Serum Using a Novel Homogeneous Assay," was awarded Poster of Distinction by the DDW sponsoring societies.

About Prometheus

Prometheus Laboratories Inc. is committed to improving lives through the development and commercialization of novel pharmaceutical and diagnostic products that enable physicians to provide greater individualized patient care. Prometheus is a leader in applying the principles of personalized medicine to the diagnosis and treatment of gastrointestinal diseases and is applying these principles to oncology. Its strategy includes the marketing and delivery of pharmaceutical products complemented by proprietary diagnostic testing services. By integrating therapeutics and diagnostics, Prometheus believes it can provide physicians with a comprehensive solution to treat chronic diseases. Prometheus' corporate offices are located in San Diego, California.

(1)Afif W et al. Clinical utility of measuring infliximab and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease. Am J Gastroenterol. 2010 May;105(5):1133-9.


'/>"/>
SOURCE Prometheus Laboratories Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Prometheus Acquires Exclusive Rights to PROLEUKIN(R) (aldesleukin) in the U.S.
2. Prometheus Launches ProOnc Dx Cancer Diagnostics
3. Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW
4. Prometheus and Rosetta Genomics Announce License and Collaboration Agreement
5. Prometheus Presents Findings From Development of PROMETHEUS(R) IBS Diagnostic, First Blood Test for IBS, at ACG Annual Scientific Meeting
6. DUSA Pharmaceuticals Announces Slate of Nominees for Election to the Board of Directors
7. Ferring Pharmaceuticals Announces Disco Icon Gloria Gaynor as National Spokesperson for EUFLEXXA(R)
8. Octapharma USA Announces Availability and Distributors for wilate®, the First Replacement Therapy Developed Specifically for von Willebrand Disease
9. Cogdell Spencer Announces Commencement of Common Stock Offering
10. Mylan Announces Upsizing and Pricing of Senior Notes
11. Mettler-Toledo International Inc. Announces Webcast of Presentation at Baird Growth Stock Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... , Jan. 23, 2017  HOPE BIOSCIENCES announced ... to develop and commercialize nuc -gemcitabine™ (APTA-12/HOPE-888) ... Korean pharmaceutical company. nuc -Gemcitabine ... against surface nucleolin found on many cancer cells, ... ADCs (antibody drug conjugates) or SMDCs (small molecule ...
(Date:1/23/2017)... ROCKVILLE, Md. , Jan. 23, 2017 /PRNewswire/ ... to advancing a new standard in respiratory care, ... Committee for Orphan Medicinal Products has granted Orphan ... the treatment of Bronchiolitis Obliterans Syndrome (BOS).  ... Drug Designation from the EMA to treat patients ...
(Date:1/23/2017)... Jan. 23, 2017  Based on its recent ... Sullivan recognizes Ansell, a global leader in protection ... Company of the Year Award. Ansell,s comprehensive product ... wide global footprint have placed it in a ... market. The Company,s established product line and robust ...
Breaking Medicine Technology:
(Date:1/24/2017)... , ... January 24, 2017 , ... ... visualize, detect, and eliminate cyber threats in real-time, today announced a strategic partnership ... will enable customers to monitor, respond and protect their critical information assets and ...
(Date:1/24/2017)... ... ... His message has been heard by more than 100,000 students and adults across ... Feldman, has reached his biggest national audience yet: the three million daily readers of ... circulation in the country, and he hopes it will help spread his message and ...
(Date:1/24/2017)... ... January 24, 2017 , ... This Saturday, January 28, the BCFA ... very special performance by Alabama Symphony Orchestra musicians Yifan Zhou, Mara McClain & Sarah ... dim sum, and exhibitors offer a look at Chinese games, crafts & more. Festivities ...
(Date:1/24/2017)... Boston, MA (PRWEB) , ... January 24, 2017 ... ... What They Really Need to Thrive , Well-meaning studies such as the Fordham ... and schools can better serve top students, such as including gifted or high-achieving ...
(Date:1/24/2017)... ... January 24, 2017 , ... Date aired: ... , Sharon Kleyne, the nation’s foremost water advocate and host of the nationally ... Health on Voice America, once again welcomed one of her favorite guests and ...
Breaking Medicine News(10 mins):