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Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW
Date:6/2/2009

tions ranged between 2.2 EU/mL and 4.3 EU/mL. These results are consistent with reports in the scientific literature suggesting biomarker stability over similar time periods. Further studies are required to evaluate the impact of therapy on biomarker stability over longer periods of time.

The clinical utility of PROMETHEUS IBD Serology 7 was further demonstrated in a separate, multi-center clinical study of an additional 1,574 patient samples, increasing the total development cohort of the test to a more heterogeneous 3,626 patient samples. Results with this large patient cohort further confirmed that using multiple markers combined with Prometheus' Smart Diagnostic Algorithm is more effective at differentiating IBD vs. non-IBD and Crohn's disease vs. ulcerative colitis than using traditional cutoff value analysis of the individual markers alone. PROMETHEUS IBD Serology 7 combines multiple serologic markers with a proprietary Smart Diagnostic Algorithm, which increases the sensitivity of the test by more than 25% when compared to single marker sensitivity values.

About Celiac

Celiac disease is an immune-mediated digestive disease that is triggered by the consumption of gluten and damages the small intestine, interfering with the absorption of nutrients from food. Gluten is a protein found in grains such as wheat, barley and rye. Symptoms of celiac disease will vary significantly from person to person and include, but are not limited to, diarrhea, anemia, abdominal pain, skin rash and weight loss. It is estimated that about 1% of people in the United States live with celiac disease and the disease is greatly undiagnosed. The number of diagnosed patients is expected to increase significantly over the next several years, driven by broad-based educational campaigns, National Institutes of Health research funding and widely-available genetic and blood tests for highly-specific antibodies.

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SOURCE Prometheus Laboratories Inc.
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