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Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients
Date:12/8/2008

ith 7 percent in the VAD arm (p=0.0035). -- After the first performed ASCT, CR/nCR rates were 40 percent in the VcD arm, compared with 22 percent in the VAD arm (p=0.0001). -- After the first performed ASCT, very good partial response (VGPR) or better rates were 61 percent in the VcD arm, compared with 44 percent in the VAD arm (p=0.0007). -- Thirty-four percent of patients in the VcD arm required a second ASCT, compared with 47 percent of patients in the VAD arm. -- Serious adverse events were reported in 27 percent of the VcD patients, compared with 34 percent of the VAD patients.

"The data from patients treated with VELCADE and dexamethasone prior to transplantation showed significantly longer progression-free survival," said Jean-Luc Harousseau, M.D., Hospital Hotel-Dieu and Principal Investigator of the trial. "We are interested in whether this will translate into extended overall survival for these patients with previously untreated multiple myeloma when the follow-up duration is sufficient."

Patients in the VcD arm received VELCADE at 1.3 mg/m(2) on days 1, 4, 8 and 11 and dexamethasone at 40 mg on days 1 through 4 during cycles 1 through 4 and days 9 through 12 during only the first and second cycles. Patients in the VAD arm received vincristine at 0.4 mg/m(2) and doxorubicin at 9 mg/m(2) on days 1 through 4, and dexamethasone at 40 mg on days 1 through 4 during cycles 1 through 4 and on days 9 through 12 and 17 through 20 during only the first and second cycles.

Superior Complete Response Rate and Progression-Free Survival After Autologous Transplantation with Up-Front VELCADE-Thalidomide-Dexamethasone Compared with Thalidomide-Dexamethasone in Newly Diagnosed Multiple Myeloma (Abstract #158)

In a Phase III study conducted by the Italian Myeloma Network GIMEMA, researchers compared VcTD with TD as induction therapy in
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SOURCE Millennium: The Takeda Oncology Company
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