Navigation Links
Prolong Pharmaceuticals Presents Novel Multi-Pronged Approach To Treating Sickle Cell Disease At The SCDAA Meeting
Date:9/26/2013

gned to have multiple mechanisms of action that interrupt both of these key pathways at several points.  It is an intravenous therapeutic that combines the beneficial functions of a carbon monoxide releasing molecule, an oxygen transfer agent and a plasma expander. The carbon monoxide is released, promoting anti-inflammatory and anti-vasoconstriction effects while the oxygen transfer component facilitates the movement of oxygen from regions of high oxygen concentration to regions of low oxygen concentration.  A polymer provides further benefit by improving blood flow, viscosity and acts as a plasma expander. In addition, the size of this therapeutic molecule allows it to move through obstructed blood vessels where red blood cells, due to their size, are unable to travel.  Collectively, these features permit SANGUINATE to act on multiple targets in the pathway, thereby halting the destructive effects of hemolysis and oxygen deprivation. Researchers have identified several therapeutic strategies for treating the comorbidities of SCD which SANGUINATE addresses:

  • Increases the amount of oxygen carrying hemoglobin in the blood
  • Prevents constriction of blood vessels
  • Inhibits damaging inflammation
  • Inhibits cell adhesion, a known cause of ischemia
  • Acts as plasma expander to lower blood viscosity
  • Treats the underlying cause of ischemic pain

Short of a "cure", Prolong believes that the only way to truly lessen the overall health burden is to focus on treating these comorbidities. "We are just beginning to evaluate SANGUINATE in clinical studies and we can only hope that it proves to be effective in treating several of the comorbidities in Sickle Cell patients. Safety and efficacy studies are underway around the world," stated Dr. Abuchowski.

About SANGUINATE™

SANGUINATE™ is an investigational biopharmaceutical product th
'/>"/>

SOURCE Prolong Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Flexions Lead Osteoarthritis Drug Candidate Demonstrates Significant, Prolonged Improvement in Pain and Function in Phase 2 Trial
2. Prolong TM, a New Revolutionary First Line Treatment for Premature Ejaculation is Licensed in Europe
3. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
4. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
5. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
6. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
7. Icahn Issues Statement Regarding Amylin Pharmaceuticals
8. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
11. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... NEW YORK , Sept. 2, 2015 /PRNewswire/ ... devices are artificial implants used to replace, augment, ... used in a wide range of applications including ... These implants are made of different materials such ... analysts forecast the global implantable medical devices market ...
(Date:9/2/2015)... -- About Neuroendovascular Coil A ... and ruptured brain aneurysm (a weakened area in ... as an endovascular coiling or endovascular embolization. During ... flow in an aneurysm. The endovascular coiling treatment ... interventional neuroradiologist using fluoroscopic imaging guidance. Neuroendovascular coils ...
(Date:9/2/2015)... -- About Chronic Lymphocytic Leukemia Chronic ... production of lymphocytes. It has been observed that the ... to other parts of the body. This leukemia is ... buildup of the cancerous cells. During the course of ... and lymph nodes. The course of the disease is ...
Breaking Medicine Technology:Global Implantable Medical Devices Market 2015-2019 2Global Neuroendovascular Coil Market 2015-2019 2Global Chronic Lymphocytic Leukemia Therapeutics Market 2015-2019 2Global Chronic Lymphocytic Leukemia Therapeutics Market 2015-2019 3
...  Premier Research Group announces the appointment of Susan ... Vice President, Clinical Development. In this position, Dr. ... developing the company,s clinical trial management services provided ... industry knowledge and proven leadership skills will be ...
...  LIQUENT, Inc. the global leader in regulatory information ... LIQUENT,s XEVMPD Educational Series and Data Assessment tool. ... the July 2012 deadline for submitting product information ... LIQUENT,s XEVMPD Educational Series is ...
Cached Medicine Technology:Premier Research Names Susan Stansfield, PhD Executive VP, Clinical Development 2LIQUENT Announces XEVMPD Educational Series and Data Assessment Tool 2
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... robust distribution channels and efficient customer and technical support services to promote LodonalTM ... approved 90-day Bridging trial evaluating the efficacy and safety of the product. , ...
(Date:9/2/2015)... ... September 03, 2015 , ... Leah Binder, MA, MGA, ... influential leaders in healthcare, will offer the keynote address at the upcoming meeting ... 2015, in Palm Harbor, Florida, at the Innisbrook Resort and Golf Club. For ...
(Date:9/2/2015)... Washington, DC (PRWEB) , ... September 03, 2015 ... ... stacks of nominations to determine who among America’s policymakers, public servants, activists, corporate ... on the nation’s health care. This year, that process led the magazine to ...
(Date:9/2/2015)... (PRWEB) , ... September 02, ... ... the 2015 Warrior-Family Symposium (WFS), cosponsored by the Military Officers Association of ... During the event, "Our Nation's Military: Caring For Our Own,” expert panelists ...
(Date:9/2/2015)... Los Angeles, CA (PRWEB) , ... September 02, 2015 , ... ... working to expand their fleet of truly superb luxury vehicles based on which of ... are pleased to announce the latest step forward in pursuit of this goal: a ...
Breaking Medicine News(10 mins):Health News:Fidson Partners US Firms on New Product Marketing 2Health News:Fidson Partners US Firms on New Product Marketing 3Health News:Fidson Partners US Firms on New Product Marketing 4Health News:ACO Coalition Meeting to Feature Leapfrog’s Leah Binder 2Health News:ACO Coalition Meeting to Feature Leapfrog’s Leah Binder 3Health News:NLN CEO Dr. Beverly Malone Named One of 100 Most Influential in Health Care 2Health News:NLN CEO Dr. Beverly Malone Named One of 100 Most Influential in Health Care 3Health News:MOAA and WWP host 2015 Warrior-Family Symposium Chairman of the Senate Committee on Veterans' Affairs and the Secretary of Veterans Affairs to Speak 2Health News:MOAA and WWP host 2015 Warrior-Family Symposium Chairman of the Senate Committee on Veterans' Affairs and the Secretary of Veterans Affairs to Speak 3Health News:Luxury Line Auto Rental Announces Addition of the Rolls Royce Wraith to their Luxury Fleet 2
... with demand. Two experts in this weeks BMJ debate whether ... there is evidence to the contrary is the answer. ... support organ donation, yet only 23% have registered their wish ... at the British Medical Association. ,Research indicates that ...
... robotic technology may improve survival rates for prostate ... Thomas Jefferson University Hospitals multidisciplinary Genitourinary (GU) cancer ... 21, 2007 at the annual American Urological Society ... that performing a laparoscopic radical prostatectomy (LRP) with ...
... 10-fold over the past 40 years in England, owing to ... finds research published ahead of print in the British ... wide geographical variation in rates suggest that the NHS is ... and training, say the authors. ,The research team ...
... Researchers at Jefferson Medical College have shown that capsule ... small bowel Crohns disease in children. The technology has ... more than five years to diagnose unexplained abdominal bleeding ... is not much bigger than a vitamin pill and ...
... In a move to improve global public health, Weill ... heart disease drug onto the World Health Organization's ... guideline for developing countries to choose which high-priority drugs ... ,Students from Weill Cornell's chapter of Universities Allied for ...
... young to speak or crawl, but they can certainly tell ... with only visual cues. ,Researcher Whitney Weikum ... able to discern when a different language is spoken by ... face movements. ,The findings suggest that babies growing ...
Cached Medicine News:Health News:Is Presumed Consent the Answer to Organ Shortages? 2Health News:Robotic Surgery May Improve Survival Rate For Prostate Cancer Patients 2Health News:NHS Oversupplied With Cataract Surgery, Say Doctors 2Health News:Medical College Students Help Change Global Health Policy 2Health News:Even at Four Months, Babies can Tell When Speakers Switch Languages 2
Diareader ELX800G...
Plate Reader is an eight channel photometer for the sequential and simultaneous reading of micro-plate strips with 96 wells. High technology, user friendly, powerful and reliable....
... certified microstrip reader. Stat fax 303 ... to use with step-by-step prompting and ... other programming enhancements. On-board software calculates ... & a variety of cutoff options. ...
Iems Incubator/Shaker expansion module for 2 module incubator/shaker. high performance microplate incubator and orbital shaker. It's superior temperature control and efficient orbital shaking reduce ...
Medicine Products: