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Prolong Pharmaceuticals Presents Novel Multi-Pronged Approach To Treating Sickle Cell Disease At The SCDAA Meeting
Date:9/26/2013

gned to have multiple mechanisms of action that interrupt both of these key pathways at several points.  It is an intravenous therapeutic that combines the beneficial functions of a carbon monoxide releasing molecule, an oxygen transfer agent and a plasma expander. The carbon monoxide is released, promoting anti-inflammatory and anti-vasoconstriction effects while the oxygen transfer component facilitates the movement of oxygen from regions of high oxygen concentration to regions of low oxygen concentration.  A polymer provides further benefit by improving blood flow, viscosity and acts as a plasma expander. In addition, the size of this therapeutic molecule allows it to move through obstructed blood vessels where red blood cells, due to their size, are unable to travel.  Collectively, these features permit SANGUINATE to act on multiple targets in the pathway, thereby halting the destructive effects of hemolysis and oxygen deprivation. Researchers have identified several therapeutic strategies for treating the comorbidities of SCD which SANGUINATE addresses:

  • Increases the amount of oxygen carrying hemoglobin in the blood
  • Prevents constriction of blood vessels
  • Inhibits damaging inflammation
  • Inhibits cell adhesion, a known cause of ischemia
  • Acts as plasma expander to lower blood viscosity
  • Treats the underlying cause of ischemic pain

Short of a "cure", Prolong believes that the only way to truly lessen the overall health burden is to focus on treating these comorbidities. "We are just beginning to evaluate SANGUINATE in clinical studies and we can only hope that it proves to be effective in treating several of the comorbidities in Sickle Cell patients. Safety and efficacy studies are underway around the world," stated Dr. Abuchowski.

About SANGUINATE™

SANGUINATE™ is an investigational biopharmaceutical product th
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SOURCE Prolong Pharmaceuticals
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