Navigation Links
Prolong Pharmaceuticals Presents Novel Multi-Pronged Approach To Treating Sickle Cell Disease At The SCDAA Meeting

SOUTH PLAINFIELD, N.J., Sept. 26, 2013 /PRNewswire/ -- Prolong Pharmaceuticals LLC, a biopharmaceutical company dedicated to developing products for the treatment of anemia resulting from oxygen deficiency and hemolysis, presented a novel approach to treating the comorbidities of sickle cell disease (SCD) at the 41st Sickle Cell Disease Association of America convention "Moving Forward: Advocating for New Discoveries, Advancements and Breakthroughs."  The SCDAA meeting is currently underway in Linthicum, Maryland.  

(Logo: )

Sickle Cell Disease (SCD) is a blood disorder caused by a defective hemoglobin molecule resulting in the production of abnormally shaped and fragile red blood cells.  These sickle cells break down very readily in a process called hemolysis, and also cause ischemia (restricted blood flow).  These two interrelated events lead to damaging inflammation, production of toxic waste products and further deprive cells and tissues of a critical oxygen supply.  Although SCD is a clearly defined genetic disease, patients suffer from a host of comorbidities resulting from these events.  Unless both of these disease pathways are interrupted, cell death, tissue damage and organ dysfunction can result.

At the scientific session, Abraham Abuchowski, Ph.D., Chief Scientific Officer and CEO, stated, "It has become evident that no single approach will be sufficient to treat the comorbidities of SCD such as pain, stroke, dactylitis and leg wounds. The best hope to reducing these complications will be a product that acts early on in the disease and at multiple target sites.  SANGUINATE™ holds the promise of reducing or preventing the comorbidities of SCD."

Prolong's product, SANGUINATE, has been designed to have multiple mechanisms of action that interrupt both of these key pathways at several points.  It is an intravenous therapeutic that combines the beneficial functions of a carbon monoxide releasing molecule, an oxygen transfer agent and a plasma expander. The carbon monoxide is released, promoting anti-inflammatory and anti-vasoconstriction effects while the oxygen transfer component facilitates the movement of oxygen from regions of high oxygen concentration to regions of low oxygen concentration.  A polymer provides further benefit by improving blood flow, viscosity and acts as a plasma expander. In addition, the size of this therapeutic molecule allows it to move through obstructed blood vessels where red blood cells, due to their size, are unable to travel.  Collectively, these features permit SANGUINATE to act on multiple targets in the pathway, thereby halting the destructive effects of hemolysis and oxygen deprivation. Researchers have identified several therapeutic strategies for treating the comorbidities of SCD which SANGUINATE addresses:

  • Increases the amount of oxygen carrying hemoglobin in the blood
  • Prevents constriction of blood vessels
  • Inhibits damaging inflammation
  • Inhibits cell adhesion, a known cause of ischemia
  • Acts as plasma expander to lower blood viscosity
  • Treats the underlying cause of ischemic pain

Short of a "cure", Prolong believes that the only way to truly lessen the overall health burden is to focus on treating these comorbidities. "We are just beginning to evaluate SANGUINATE in clinical studies and we can only hope that it proves to be effective in treating several of the comorbidities in Sickle Cell patients. Safety and efficacy studies are underway around the world," stated Dr. Abuchowski.


SANGUINATE™ is an investigational biopharmaceutical product that has a multiple mechanisms of action designed to release therapeutic carbon monoxide and actively transfer oxygen to hypoxic tissue. SANGUINATE™ has completed Phase I safety trials and preparing to launch Phase II trials in SCD patients.

About Prolong Pharmaceuticals 

Headquartered in South Plainfield, New Jersey, Prolong Pharmaceuticals, LLC is developing products to treat several diseases and their debilitating comorbidities which cause reduced quality of life, increased medical cost and significant mortality. The company's lead product, SANGUINATE™, is in clinical testing, focused on treating the comorbidities of sickle cell disease and other disorders where oxygen deprivation due to hemolysis and/or ischemia occurs.  The company's senior management team includes inventors of the most successful drug delivery technology in pharmaceutical history, PEGylation, now responsible for more than $30 billion in drug sales worldwide. For more information visit:

SOURCE Prolong Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Flexions Lead Osteoarthritis Drug Candidate Demonstrates Significant, Prolonged Improvement in Pain and Function in Phase 2 Trial
2. Prolong TM, a New Revolutionary First Line Treatment for Premature Ejaculation is Licensed in Europe
3. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
4. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
5. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
6. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
7. Icahn Issues Statement Regarding Amylin Pharmaceuticals
8. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
11. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
Post Your Comments:
(Date:11/24/2015)... November 25, 2015 The hope ... repeated failure of IVF cycles. After failure of over ... and had lost all hopes that she would be able to conceive ever. ... child conceived after failure of over 15 IVF cycles. ... before they decided to take one last attempt with Gaudium IVF ...
(Date:11/24/2015)... 2015  Thanks to a donor with a personal ... Center,s Sister Diane Grassilli Center for Women,s Health now ... San Francisco . Fred ... with a gift of $617,320 that allowed the Center ... Tomosynthesis and Whole Breast Ultrasound. Tomosynthesis, three-dimensional (3-D) mammography ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... 2015 , ... Finnleo, a leader in the traditional and far-infrared sauna industry, ... far-infrared saunas. , For traditional saunas, Finnleo is offering 20% off ... and Finnleo uses only European Grade A Nordic White Spruce from sustainably grown trees. ...
(Date:11/25/2015)... ... November 26, 2015 , ... Ministers, ... Union (EU), ANDI Pan African Centres of Excellence, and public R&D institutions, civil ... for the opening of the 5th African Network for Drugs and Diagnostics Innovation, ...
(Date:11/25/2015)... FL (PRWEB) , ... November 25, 2015 , ... ... center, is encouraging people across the country to celebrate their sobriety and show ... people to post “before and after” photos this Thanksgiving with the hashtag #FacesOfGratitude ...
(Date:11/25/2015)... ... November 25, 2015 , ... The McHenry County law firm of Botto ... by Attorneys Francisco J. Botto and Alex C. Wimmer. Attorneys Botto and Wimmer represented ... IL App (2d) 130884WC. , According to court documents, Adcock testified that on May ...
(Date:11/25/2015)... ... , ... Beddit® has launched a new Android app for use ... a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and makes ... by a proprietary algorithm. Beddit analyzes the data to provide an easy to understand ...
Breaking Medicine News(10 mins):