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Progress Against Malaria and Other Infectious Diseases Among Highlights at Annual Vaccine Conference
Date:4/27/2009

demics that currently kill thousands of people."

Improvements to Avian Influenza Vaccine

Researchers from sanofi pasteur will present findings that indicate the company's bird-flu vaccine, licensed by the U.S. Food and Drug Administration in 2007, may be able to cover many more people than originally estimated through the introduction of an oil-in-water-based adjuvant. In a Phase I trial involving 375 volunteers, the company found that addition of the adjuvant to a smaller amount of antigen per dose was effective in boosting antibody response. The response also demonstrated cross-protection with a different strain of the bird flu virus than the strain from which the vaccine was made. A Phase II trial of the adjuvant vaccine, aimed at the lethal H5NI bird flu virus, is to begin by the end of 2009.

Once fully developed, this vaccine could increase sanofi pasteur's potential supply from several hundred million doses to, perhaps, several billion doses in a pandemic situation, company officials said.

Ginamarie Foglia, DO, MPH, director of clinical development at sanofi pasteur, said the results indicate that the licensed vaccine may provide some protection even against a pandemic caused by a different strain of H5N1. She also noted it may make sense to vaccinate people prior to a pandemic with the licensed vaccine and then, if a pandemic breaks out, administer a booster shot of a vaccine made with the pandemic strain.

Boosting Influenza Vaccine Coverage among School-Age Children

While the bird-flu scare in Southeast Asia has captured the public imagination, researchers from Texas A&M Health Science Center and Baylor College of Medicine will report progress against a more common threat - seasonal influenza.

In the Temple-Belton area of central Texas, medical professionals have teamed up with local school districts
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SOURCE National Foundation for Infectious Diseases
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