Navigation Links
Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A
Date:7/22/2008

BRISBANE, Australia, July 22 /PRNewswire-FirstCall/ -- Following a thorough review that concluded late yesterday, the Board of Progen Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) today announced that it had discontinued the PI-88 phase 3 study in liver cancer. Progen confirmed its strategic direction to develop its existing portfolio of compounds and the company will actively seek to acquire additional compounds and opportunities through Merger & Acquisition activity.

The strategic review was triggered by a recent accumulation of a number of factors that impacted the commercial return for the phase 3 PATHWAY trial.

The trial is unlikely to meet the forecast patient recruitment timetable and further significant delays were expected due to:

-- slower than expected regulatory processes in China, Korea and Vietnam;

-- slower than expected initiation of clinical sites;

-- slower than expected recruitment of patients into active sites; and

-- the recent launch of a competitive phase 3 trial, assessing Bayer/Onyx Nexavar(R) in the same indication.

Due to a lack of a global partner willing to meaningfully develop and commercialise PI-88, the commercial opportunity is much less than previously expected. Without a significant global partner contributing, Progen will be less able to expand into additional indications and exploit all potential PI-88 commercial opportunities.

These aspects would have delayed market entry significantly and seriously impacted on the commercial return of the phase 3 PATHWAY trial.

The next step is that Progen will seek expressions of interest in PI-88, at a regional level, initially from amongst those parties that had entered into Non-Disclosure Agreements and Due Diligence on PI-88.

The PI-88 trial had been facilitated through external agencies, and had resulted in 23 sites being opened for patient recruitment and 12 patients from 5 recruitment centres having be
'/>"/>

SOURCE Progen Pharmaceuticals Limited
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Presentation of Data on Progens Cancer Epigenetic Targets Platform
2. Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations
3. Progen Resumes Phase 1 Development of Anti-Cancer Agent, PG-11047
4. Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials
5. Progen Announces Commencement of Global Phase 3 Study for PI-88 in Post- Resection Liver Cancer
6. Progen Provides Update on Phase 3 Clinical Program for PI-88 in Liver Cancer
7. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
8. Progen Announces PI-88 Phase 2 Lung Cancer Results
9. Progen Pharmaceuticals Announces Fiscal 2007 Financial Results
10. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
11. Nektar Terminates All Negotiations With Potential Partners for Inhaled Insulin; Increased Number of Lung Cancer Cases Observed in Ongoing Clinical Studies of Inhaled Insulin Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... , March 4, 2015  Results of the ... Consecutive Cases Using MarginProbe for Intra-Operative Positive Margin Detection ... session at the 32 nd Annual Miami Breast ... conducted by Moshe Papa , MD, FACS, Professor ... Tel Aviv University, reports an analysis of MarginProbe,s efficiency ...
(Date:3/4/2015)... 2015  Bayer HealthCare today announced that the ... the company,s Biologics License Application (BLA) for BAY ... seeking FDA approval of the investigational compound, proposed ... A in children and adults. ... to hemophilia A patients who need them," said ...
(Date:3/4/2015)... -- Heska Corporation (Nasdaq: HSKA ) announces the ... Fourth Quarter and Year End 2014 Earnings Conference Call ... (MST) / 11:00 a.m. (EST)Where: www.heska.com (click on ... on the front page of this website)How:Live over the ... the address above.  Alternatively, you may use the following ...
Breaking Medicine Technology:New Study Shows Breast Re-excision Rates Significantly Reduced in 100 Consecutive Cases 2FDA Accepts Bayer's Biologics License Application for Investigational Treatment Option in Hemophilia A 2FDA Accepts Bayer's Biologics License Application for Investigational Treatment Option in Hemophilia A 3Webcast Alert: Heska Announces Fourth Quarter and Year End 2014 Earnings Conference Call Webcast 2
(Date:3/4/2015)... (PRWEB) March 04, 2015 With the growing ... the lives of our teens and young adults, combined with ... difficult and confusing to try to keep up with what ... fad or trend is replaced on a daily basis. , ... substances, and the slang that is used to discreetly talk ...
(Date:3/4/2015)... March 04, 2015 Alliance Healthcare Foundation ... wellness for those in need in San Diego and ... organizations through its Mission Support Grants program with awards ... organizations applied for AHF’s Mission Support Grants program. Grant ... board of trustees and program committee, as well as ...
(Date:3/4/2015)... March 04, 2015 The Global ... billion in 2014 and is estimated to grow ... of 4.0% from 2014 to 2019. , Browse ... Market for an analysis of industry trends, segments ... global liquefied petroleum gas market is classified into ...
(Date:3/4/2015)... RapidScale, a global cloud services innovator, is ... March 16th-18th. They are hosting Booth #1010 on the ... top engineering executives in attendance to provide demos and ... Attendees include William Hiatt, CTO; Jeff Richards, Cloud Delivery ... Cloud Support Manager. , RapidScale is also hosting ...
(Date:3/4/2015)... According to a new report published ... the U.S. suffer from gastroesophageal reflux disease (GERD), more ... to control acid production, but these can have side ... the problem and lead to other uncomfortable digestive conditions. ... the lower esophageal sphincter does not function properly. Anti-reflux ...
Breaking Medicine News(10 mins):Health News:Per Wickstrom Offers Guide to Parents for Keeping Youth Sober 2Health News:Alliance Healthcare Foundation Awards $1 million through Mission Support Grants Program 2Health News:Alliance Healthcare Foundation Awards $1 million through Mission Support Grants Program 3Health News:The Global Liquefied Petroleum Gas Market is Estimated to Reach $288.7 Billion by 2019 - A Report by MicroMarket Monitor 2Health News:The Global Liquefied Petroleum Gas Market is Estimated to Reach $288.7 Billion by 2019 - A Report by MicroMarket Monitor 3Health News:Rapidscale to Host First Cloudtalk Events at Channel Partners in Las Vegas 2Health News:Rapidscale to Host First Cloudtalk Events at Channel Partners in Las Vegas 3Health News:New and Proven Acid Reflux Treatments Offer Relief to Millions of Americans 2Health News:New and Proven Acid Reflux Treatments Offer Relief to Millions of Americans 3
... who were taken care of by their grandparents during childhood, ... as they age . ,The University of Haifa ... received their care and concern, were more likely to look ... little things, like occasional babysitting for a few hours were ...
... Scientists have made significant advances towards the development of a ... infected with variant CJD . ,The technique, which ... by mimicking and accelerating the replication of prions - abnormal ... to cause the disease. ,The method, known as ...
... need no longer be embarrassed about going to school during ... has introduced toilets with incinerators to dispose of sanitary wastes ... also taken steps to educate girls above 10 about menstruation ... body, and are prepared to tackle them. ,"We ...
... ,Pull on rubber gloves. ,Smear Vaseline over your glasses , ,and there you have it: ... ... - Malcolm Cowley ,Hormone Replacement ... estrogen and often progesterone for post-menopausal women. ,The two major ...
... parents Serge and Herbethe Elie have welcomed their seventh daughter who ... the seventh year of the millennium . ,Elizabeth Elie, who ... in delivery room No 7, also happens to be the seventh ... will bestow good luck on his newborn daughter, and that he ...
... World Wildlife Fund (WWF), has expressed fears about global warming ... . ,According to them, the Tibet faces the possibility ... rivers drying up. ,The scientists came to their ... the Qinghai-Tibet Plateau. ,"The glaciers at the ...
Cached Medicine News:Health News:Grandparents' Care Makes Grandchildren More Caring for Them 2Health News:Significant Advances in VCJD Prion Detection 2Health News:Hormone Replacement Therapy Liberation at a Cost 2Health News:Hormone Replacement Therapy Liberation at a Cost 3Health News:Global Warming Threatens Tibet 2
Creatinine Test Kit (enzymatic, liquid reagents), Wavelength: 550 nm. Linear range: up to 150 mg/dL....
For the quantitative determination of creatinine in serum. Fixed Time Reaction measured at 540 nm. Linearity: 25 mg/dl. Express Kit with Ready-to-Use Liquid....
Intended for the quantitative determination of magnesium in serum. Wavelength: 340 nm. Linearity: 9.7 mg/dL (4 mmol/L). Two vials, dry powder reagents....
Glucose reagent is used for the quantitative determination of glucose in human serum....
Medicine Products: