Navigation Links
Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A
Date:7/22/2008

BRISBANE, Australia, July 22 /PRNewswire-FirstCall/ -- Following a thorough review that concluded late yesterday, the Board of Progen Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) today announced that it had discontinued the PI-88 phase 3 study in liver cancer. Progen confirmed its strategic direction to develop its existing portfolio of compounds and the company will actively seek to acquire additional compounds and opportunities through Merger & Acquisition activity.

The strategic review was triggered by a recent accumulation of a number of factors that impacted the commercial return for the phase 3 PATHWAY trial.

The trial is unlikely to meet the forecast patient recruitment timetable and further significant delays were expected due to:

-- slower than expected regulatory processes in China, Korea and Vietnam;

-- slower than expected initiation of clinical sites;

-- slower than expected recruitment of patients into active sites; and

-- the recent launch of a competitive phase 3 trial, assessing Bayer/Onyx Nexavar(R) in the same indication.

Due to a lack of a global partner willing to meaningfully develop and commercialise PI-88, the commercial opportunity is much less than previously expected. Without a significant global partner contributing, Progen will be less able to expand into additional indications and exploit all potential PI-88 commercial opportunities.

These aspects would have delayed market entry significantly and seriously impacted on the commercial return of the phase 3 PATHWAY trial.

The next step is that Progen will seek expressions of interest in PI-88, at a regional level, initially from amongst those parties that had entered into Non-Disclosure Agreements and Due Diligence on PI-88.

The PI-88 trial had been facilitated through external agencies, and had resulted in 23 sites being opened for patient recruitment and 12 patients from 5 recruitment centres having be
'/>"/>

SOURCE Progen Pharmaceuticals Limited
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Presentation of Data on Progens Cancer Epigenetic Targets Platform
2. Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations
3. Progen Resumes Phase 1 Development of Anti-Cancer Agent, PG-11047
4. Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials
5. Progen Announces Commencement of Global Phase 3 Study for PI-88 in Post- Resection Liver Cancer
6. Progen Provides Update on Phase 3 Clinical Program for PI-88 in Liver Cancer
7. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
8. Progen Announces PI-88 Phase 2 Lung Cancer Results
9. Progen Pharmaceuticals Announces Fiscal 2007 Financial Results
10. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
11. Nektar Terminates All Negotiations With Potential Partners for Inhaled Insulin; Increased Number of Lung Cancer Cases Observed in Ongoing Clinical Studies of Inhaled Insulin Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... , Aug. 28, 2014  Decision Resources ... market will grow strongly through 2022 at a ... This will be largely supported by strong population ... increase demand for imaging procedures. The Indian government,s ... more facilities to purchase or upgrade diagnostic imaging ...
(Date:8/28/2014)... OSAKA, Japan , Aug. 28, 2014 /PRNewswire/ ... completion of the post-marketing commitment and submissions of ... authorities including the United States ... European Medicines Agency (EMA) and the Japanese Ministry ... Japanese Pharmaceuticals and Medical Devices Agency (PMDA) for ...
(Date:8/28/2014)... SALT LAKE CITY , Aug. 28, 2014 /PRNewswire-iReach/ ... in 2000 by service academy graduates, has published a ... its concentrated, three-day Leadership Excellence Course . In ... the  Leadership Excellence Course to Albuquerque , ... Tucson . Photo - http://photos.prnewswire.com/prnh/20140828/140814 ...
Breaking Medicine Technology:Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 2Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 3Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 2Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 3Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 4Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 5Takeda Announces Completion of the Post-Marketing Commitment to Submit Data to the FDA, the EMA and the PMDA for Pioglitazone Containing Medicines Including ACTOS 6Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 3Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 4Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 5
... Feb. 17, 2011 Greenway Medical Technologies, Inc., an ... with HP to offer medical practices custom electronic health ... and improve quality of care. Greenway,s ... solution and HP hardware will be available to provide ...
... ATLANTA, Feb. 17, 2011 Ingenious Med, the leading ... its solution is now available on the App Store ... being launched as part of the company,s presence at ... The application enables Ingenious Med,s 9,000 users to access ...
Cached Medicine Technology:Greenway Works With HP to Offer Medical Practices Complete EHR Infrastructure 2Greenway Works With HP to Offer Medical Practices Complete EHR Infrastructure 3Greenway Works With HP to Offer Medical Practices Complete EHR Infrastructure 4HIMSS11: Ingenious Med Launches Billing and Data Capture App for iPhone, iPod touch and iPad 2
(Date:8/29/2014)... 29, 2014 As a chiropractic physician ... understands that there’s a direct connection between the condition ... and back. "Since conventional shoe inserts and orthotics weren’t ... of my own," he said. , Customizable to a ... support for the foot in order to help prevent ...
(Date:8/29/2014)... (HealthDay News) -- Researchers have discovered that people with ... Dyslexia -- the most commonly diagnosed learning disorder in ... writing. Previous research showed that brain activity is ... studies focused only on a small number of brain ... analyze how multiple brain regions use networks to communicate ...
(Date:8/29/2014)... August 29, 2014 Empty Nest ... at http://www.blogtalkradio.com/dr-carol-francis/2014/08/29/psychologist-dr-carol-francis-addressing-empty-nest-syndrome .     , Mothers and fathers, ... money, marital bliss, prodding, laughing and sweating through ... house this week. Relief and parenting pride ... what.” Dr. Carol Francis as a ...
(Date:8/29/2014)... "I have had many hospital stays, including ... many other surgeries in my lifetime, as I am a ... stays, I was unable to move freely in order to ... freely had to physically rotate me every 30 minutes to ... and pulled the sheets. This was jarring and caused me ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Scientists from ... idea that progression-free survival correlates with overall survival of ... the new research. Click here to read it ... The Netherlands studied the cases of 523 mesothelioma ... studies. , “PFSR-18 [progression-free survival at 18 weeks ...
Breaking Medicine News(10 mins):Health News:Scientists Find Differences in Brains of Those With Dyslexia 2Health News:Psychologist Dr. Carol Francis Addressing Empty-Nest Syndrome on Talk Radio Today 2Health News:Psychologist Dr. Carol Francis Addressing Empty-Nest Syndrome on Talk Radio Today 3Health News:InventHelp® Client Develops Equipment for Surgical and Bedridden Patients (HCD-279) 2Health News:European Study Says Disease Progression Predicts Mesothelioma Survival Better Than Treatment Response, According to Surviving Mesothelioma 2
... (HealthDay News) -- New genetic mapping of children with ... gene mutation are particularly well-skilled in the use of ... specific variation of the so-called "PCSK6 gene" and hand-motor ... to suggest that there could be an association between ...
... Japanese research group led by Prof. Ryusuke Kakigi and ... and Prof. Masami K Yamaguchi (Chuo University) found that ... temporal sulcus (STS) when processing positive (happy) and negative ... reported in NeuroImage . Near infrared spectroscopy ...
... , THURSDAY, Nov. 4 (HealthDay News) -- During ... clothes to keep infants warm can lead to dangerous ... syndrome (SIDS), U.S. experts warn. Infants are sensitive ... their body temperature. Research has shown that multiple layers ...
... children, especially those with eczema, are unnecessarily avoiding ... according to researchers at National Jewish Health. The ... children, and is often based primarily on data ... factors, including patient and family history, physical examination, ...
... Cambridge hope to revolutionise cancer therapy after discovering one of ... system to treat cancerous tumours have failed. New ... that a type of stromal cell found in many cancers ... role in suppressing the immune response in cancerous tumours ...
... could help smuggle drugs into the gut, according to ... Journal of Nanotechnology . There are several drugs ... could be targeted at absorption by the lower intestine. ... colon cancer for instance, medication delivered by mouth must ...
Cached Medicine News:Health News:Research Suggests Link Between 'Handedness' and Dyslexia 2Health News:Infants' hemodynamic responses to happy and angry facial expressions 2Health News:Overheating in Infants Can Lead to SIDS, Experts Warn 2Health News:Food-allergy fears drive overly restrictive diets 2Health News:Food-allergy fears drive overly restrictive diets 3Health News:Breakthrough in cancer vaccine research 2Health News:Colonic navigation 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: