Navigation Links
Progen Resumes Phase 1 Development of Anti-Cancer Agent, PG-11047
Date:5/14/2008

BRISBANE, Australia, May 14 /PRNewswire-FirstCall/ -- Progen Pharmaceuticals Limited (ASX:PGL; Nasdaq: PGLA) today announced that the Company has resumed patient enrolment in the phase 1 dose-escalation study of its recently acquired polyamine analogue, PG-11047 (formerly CGC-11047) for patients with advanced cancer.

Progen has commenced development of PG-11047 - the lead clinical compound in the Company's polyamine program - following its acquisition of Cellgate, Inc earlier this year. The first patient to be recruited into the trial re-initiation has been enrolled at the University of Chicago.

The trial is exploring the potential of PG-11047 as a single anti-cancer agent and is designed to assess the agent's maximum tolerated dose. Under CellGate, the trial had recruited 31 patients and had shown little evidence of toxicity, while using significantly higher doses than most previous studies of polyamine compounds.

Justus Homburg, Progen's CEO, said, "Since the acquisition of CellGate, we have been assessing our portfolio of clinical and pre-clinical compounds in order to determine which to drive forward. Our re-initiation of PG-11047 in phase 1 clinical development is the first step in driving potential value from our expanded portfolio of first-in-class oncology therapies."

Data from the trial will be used in parallel with a separate PG-11047 study assessing the agent in combination with other marketed anti-cancer drugs as the basis for determining potential phase 2 development. Progen expects the study to produce data within the next 12 months.

About Progen: Progen Pharmaceuticals is a globally focused biotechnology company committed to the discovery, development and commercialization of small molecule pharmaceuticals primarily for the treatment of cancer. Progen has operations in Australia and the US.

About PG-11047: PG-11047 is a polyamine analogue which modifies the production of natural polyamines. Polyamines a
'/>"/>

SOURCE Progen Pharmaceuticals Limited
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials
2. Progen Announces Commencement of Global Phase 3 Study for PI-88 in Post- Resection Liver Cancer
3. Progen Provides Update on Phase 3 Clinical Program for PI-88 in Liver Cancer
4. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
5. Progen Announces PI-88 Phase 2 Lung Cancer Results
6. Progen Pharmaceuticals Announces Fiscal 2007 Financial Results
7. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
8. Biopure Announces Publication of Phase II Proof-of-Concept Coronary Trial
9. NicOx Announces Initiation of First Phase 1 Study of Investigational Nitric Oxide-Donating Agent in Hypertensive Patients by Merck & Co., Inc.
10. Velcura Therapeutics, Inc. Reports Successful Phase 1 Clinical Trial of Novel Bone Disease Therapy
11. Alseres Pharmaceuticals Announces 12 Month Interim Results from the Phase I/IIa Cethrin(R) Clinical Trial in Acute Spinal Cord Injury

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/1/2009)..., Dec. 1 Reportlinker.com announce...n its catalogue: ,, HPLC Systems & Accesso...portlinker.com/p0164366/HPLC-Systems--Accessories-..., Liquid Chromatography has emerged as a workhorse...d and beverage, research and development, and indu...
(Date:12/1/2009)...TION, N.J., Dec. 1 Merck & Co.... Administration (FDA) has approved ZEGERID OTC(TM)...ules), for over-the-counter treatment of frequent ...counter by Schering-Plough HealthCare Products, In...; Co., Inc. Schering-Plough and Merck merged on No...
(Date:12/1/2009)..., Dec. 1 Reportlinker.com announce...n its catalogue: ,, Direct to Consumer (DTC) A... Market Outlook, Regulatory Landscape and Case Stu...Direct-to-Consumer-DTC-Advertising-in-Pharmaceutic...-Landscape-and-Case-Studies.html ,, Summary ...
Breaking Medicine Technology:Reportlinker Adds HPLC Systems & Accessories - A World Market Review 2Reportlinker Adds HPLC Systems & Accessories - A World Market Review 3Reportlinker Adds HPLC Systems & Accessories - A World Market Review 4Reportlinker Adds HPLC Systems & Accessories - A World Market Review 5Reportlinker Adds HPLC Systems & Accessories - A World Market Review 6Reportlinker Adds HPLC Systems & Accessories - A World Market Review 7FDA Approves ZEGERID OTC(TM) for Over-the-Counter Treatment of Frequent Heartburn 2FDA Approves ZEGERID OTC(TM) for Over-the-Counter Treatment of Frequent Heartburn 3FDA Approves ZEGERID OTC(TM) for Over-the-Counter Treatment of Frequent Heartburn 4Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 2Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 3Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 4Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 5Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 6Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 7Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 8Advanced Life Sciences to Host 2009 Second Quarter Financial Results Conference Call and Webcast 13388 1Advanced Life Sciences to Host 2009 Second Quarter Financial Results Conference Call and Webcast 13388 2Outsourcing of IT Requirements by Healthcare Organisations Promotes All Round Benefits Says Frost 26 Sullivan 53729 1Outsourcing of IT Requirements by Healthcare Organisations Promotes All Round Benefits Says Frost 26 Sullivan 53729 2Outsourcing of IT Requirements by Healthcare Organisations Promotes All Round Benefits Says Frost 26 Sullivan 53729 3Outsourcing of IT Requirements by Healthcare Organisations Promotes All Round Benefits Says Frost 26 Sullivan 53729 4Dr Liza Solomon HIV AIDS Expert Joins Abt Associates as Principal Associate in Companys Domestic Health Division 53727 1Dr Liza Solomon HIV AIDS Expert Joins Abt Associates as Principal Associate in Companys Domestic Health Division 53727 2Dr Liza Solomon HIV AIDS Expert Joins Abt Associates as Principal Associate in Companys Domestic Health Division 53727 3
... Inc.,today announced results of a second producti...ent from all major customers and the addition of,s...tomer roster. The new,customers and existing custo...0% revenue increase, with similar growth forecaste...in/prnh/20070213/NYTU093LOGO ), A key factor in ...
...ted (ASX: BNO, US OTC: BMICY) today announced the ...he first of eight proteins licensed to US $2.6,bil..., triggering a US $1,million milestone payment., ...y 2006, Genmab,acquired the exclusive worldwide ri...d by Bionomics using its proprietary Angene(R) ang...
Other Medicine Technology:On Second Anniversary, Compendia Bioscience Announces Significant Revenue Growth, Completion of Product Milestone and Expansion of Pharma Customer Commitments 2On Second Anniversary, Compendia Bioscience Announces Significant Revenue Growth, Completion of Product Milestone and Expansion of Pharma Customer Commitments 3Bionomics Achieves US$1 Million Milestone Payment from Genmab 2Bionomics Achieves US$1 Million Milestone Payment from Genmab 3
(Date:12/1/2009)..., , BELLEVUE, Wash., Dec 1 /PRNewswire/ ...and Healthcare Channel Modernization solutions ann...slator that facilitates HIPAA 4010A1 to HIPAA 5010...e-box 4010A1-5010 conversion maps, allows generati...tween 4010A1 and 5010 in production, thus addressi...
(Date:12/1/2009)...ighest rates seen in Central and South America, st... News) -- About 50 percent of intensive care unit ...se their risk of dying in the hospital, a new stud...on a single day (May 8, 2007) on 13,796 patients, ...They found that 51 percent of patients were classi...
(Date:12/1/2009)...DC urges H1N1 vaccination because pandemic,s cours.... 1 (HealthDay News) -- A U.S. health official sai... be on the wane nationally, but many experts agree...r. , The flu is now widespread in 32 states -- ... Frieden, director of the U.S. Centers for Disease...
(Date:12/1/2009)... Practitioners of any medi...nscription are breathing a sigh of relief this wee...Phone. The application, released over the holiday...anscribe voice recordings to do so quickly and sea... (PRWEB) December 1, 2009 -- The ...
(Date:12/1/2009)..., , SMITHFIELD, R.I., Dec....ctive equipment, bad assumptions are hazardous and... years of government regulation, a handful of pers...ng both the effectiveness of occupational Hearing...ng. ,, A new free, white paper from Howard Lei...
Breaking Medicine News(10 mins):Health News:Edifecs Delivers Enhanced HIPAA 4010A1 to 5010 Migration Capabilities for Healthcare Organizations 2Health News:Edifecs Delivers Enhanced HIPAA 4010A1 to 5010 Migration Capabilities for Healthcare Organizations 3Health News:Half of ICU Patients Suffer From Infections 2Health News:Swine Flu Waning, But Could Return 2Health News:Swine Flu Waning, But Could Return 3Health News:Medical and Legal Professionals Find Relief Leveraging Apple iPhone App for Dictation and Transcription 'On the Go' 2Health News:New White Paper Details Six Common Bad Assumptions About Hearing Protection 2Health News:New White Paper Details Six Common Bad Assumptions About Hearing Protection 3
...panish scientists have reported that delaying preg...r the children. With more and more women deci...ave been resulting in delayed pregnancy for women ...his is for the first time delayed pregnancy is bei...
...cientists have reported that use of narcotics for ...kely to //ask for increasing the dose. On the othe... lead to constant increase in the dosage with seri...reating pain due to nerve damage, fibromyalgia, ar...
...ew research had showed that it is possible to use ... HIVs //genetic makeup. This is for the first...arget a part of HIV to destroy the virus in a nove...process, which works by RNA silencing, can ultimat...
... study by the computational neuroscientist of Vand...del// that will provide an insight into neural cir...r model traces the neural circuits that make us ap...velopmental process will also help the scientists ...
...dult survivors of childhood cancer may have more h... Researchers of University of Texas Southwestern M... would be from the treatment for cancer these peop...s, cirrhosis of the liver, ovarian or testicular f...
...sthma may increase the risk of bacterial infection...ngland// Journal of Medicine. Researchers had...a period of one year. For each of 635 persons with...thma by the emergency room, or the inpatient or ou...
Other Medicine News:
SYNCHRON CX5 PRO
Gastrodiagnostic Workstation
...With the advance of digital imaging technology, pa...digital formats, allowing for easier manipulation,...advance in digital pathology imaging is analogous ...h is continuing to occur in hospital imaging depar...
Roto-Dry
Medicine Products: