Navigation Links
Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
Date:11/5/2007

BRISBANE, Australia, Nov. 5 /PRNewswire-FirstCall/ -- Progen Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) today announced additional data from the Phase 2 liver cancer study of PI-88 completed earlier this year. This data was presented at the 58th Annual Meeting of the American Association for the Study of Liver Diseases in Boston, USA(1).

As the Phase 2 trial's study period covered 48 weeks from curative surgery, the data analysis described in this presentation was performed to evaluate the treatment's impact when patients with a low risk of experiencing a liver cancer recurrence within twelve months are removed from the analysis population. Patients were removed from the patient population if, based on published prognostic factors, they were considered likely to complete the 12 months of the study without recurrence.

The resultant analysis of those patients who had a high risk of recurrence in the 12-month period shows that PI-88 at least doubled the time to disease recurrence calculated at the 60th percentile (p=0.0107) (control (n=33): 24 weeks versus 160mg PI-88 (n=36): 48 weeks). This compares to a 76% improvement at the 70th percentile (p=0.0867) if all patients are included, as reported earlier this year.

Dr. James Garner, Progen's Vice President of Clinical and Medical Affairs, commented: "We know that around 50% of untreated patients are likely to experience disease recurrence within 12-15 months after they have had curative liver cancer resection. Given our Phase 2 study only assessed the recurrence of disease up to 12 months after surgery; this implies that approximately half of the study population were unable to provide information about the efficacy of the drug. When you remove from the analysis patients unlikely to recur in the study time frame, the treatment effect of PI-88 as measured in the Phase 2 study is more clearly demonstrated."

Dr. Garner further commented: "These data further expand our confidence that ou
'/>"/>

SOURCE Progen Pharmaceuticals Limited
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
2. Progen Pharmaceuticals Announces Fiscal 2007 Financial Results
3. Progen Announces PI-88 Phase 2 Lung Cancer Results
4. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
5. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
6. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
7. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
8. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
9. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
10. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
11. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... population of more than 1 billion, China is the ... potential market for goods and services. In the past ... in the average rate of growth in real GDP, ... in vitro diagnostics (IVD) market, China trails only the ... countries, and Japan. China represents one of the largest ...
(Date:9/3/2015)... 2015 About self-monitoring blood glucose device ... electronic device. It consists of a glucose sensor ... levels through radiowaves from the sensor to a ... of self-monitoring blood glucose devices can improve self-management ... proper diabetes treatment. Technavio,s analysts forecast ...
(Date:9/3/2015)... 2015 About cardiovascular implants ... narrowing or blockage of blood vessels. Cardiac disease ... high cholesterol, and high blood pressure. Coronary artery ... heart failure are some of the major cardiac ... especially coronary arteries, is one of the most ...
Breaking Medicine Technology:IVD in China 2IVD in China 3IVD in China 4IVD in China 5IVD in China 6IVD in China 7IVD in China 8IVD in China 9IVD in China 10IVD in China 11IVD in China 12IVD in China 13Global Self-monitoring Blood Glucose Devices Market 2015-2019 2Global Cardiovascular Implants Market 2015-2019 2
... SAN DIEGO, Sept. 1, 2011 Neurocrine Biosciences, Inc. (Nasdaq: ... and Chief Executive Officer of Neurocrine Biosciences, will be presenting ... The live presentation takes place on Thursday, ... a.m. Pacific Time.  The presentation will be webcast and may ...
... Sept. 1, 2011 The CVS Caremark Charitable Trust, ... a donation of $75,000 to the American Red Cross ... east coast of the United States impacted by Hurricane ... free water, ice and other supplies to local residents ...
Cached Medicine Technology:CVS Caremark Charitable Trust and CVS/pharmacy Provide Over $100,000 in Disaster Relief To Communities Impacted by Hurricane Irene 2
(Date:9/3/2015)... , ... September 04, 2015 , ... AlignLife of ... September. , "There are so many children and adults who don't have the ... Dr. Sara Mahalko-Leonhardt. "We love holding our annual Coat Drive to help those in ...
(Date:9/3/2015)... ... 03, 2015 , ... Allied Anesthesia is proud to announce a continuing partnership ... the exception. , St. Jude was recently named one of the nation’s top stroke ... one of only 10 hospitals in the state to earn the distinction. , ...
(Date:9/3/2015)... , ... September 03, 2015 , ... ... , a privately held medical technology company that will bring low-cost cancer pre-screening ... worldwide. , Preora’s proprietary and automated technology platform detects and measures cellular ...
(Date:9/3/2015)... ... 2015 , ... The Oregon Collaborative for Integrative Medicine (OCIM) ... Medicine (AIHM) Interprofessional Fellowship in Integrative Health & Medicine. The AIHM Fellowship program ... educator, physician and thought leader in integrative medicine. This is the first graduate-level, ...
(Date:9/3/2015)... ... September 03, 2015 , ... The Beryl Institute ... 2016, to be held April 13-15 at Sheraton Hotel in Dallas, Texas. Patient ... the collective voices of healthcare leaders, staff, physicians, patients and families across the ...
Breaking Medicine News(10 mins):Health News:AlignLife is Helping to Keep the Community Warm This Winter 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 2Health News:Allied Anesthesia Physicians Announce Partnership with St. Jude 3Health News:Preora Diagnostics to Commercialize Cancer Pre-screening Tests 2Health News:Preora Diagnostics to Commercialize Cancer Pre-screening Tests 3Health News:Oregon Collaborative for Integrative Medicine Partners with AIHM on First Interprofessional Fellowship 2Health News:Oregon Collaborative for Integrative Medicine Partners with AIHM on First Interprofessional Fellowship 3Health News:Patient Experience Conference 2016 Program Announced by The Beryl Institute 2Health News:Patient Experience Conference 2016 Program Announced by The Beryl Institute 3
... ... , ... - Undergraduate nursing students have an opportunity of a lifetime: write an article about ... in Madrid, Spain. , , , , ,The article writing contest is sponsored by ...
... , , , ELM ... bringing pink to your front door. , , ... at 10 AM, Aurora Health Care will join with Ace Hardware, the ... light bulbs through the month of October. A ribbon cutting ceremony ...
... , WASHINGTON, Sept. 17 ... Sox Foundation and Massachusetts General Hospital (MGH) to launch a ... Traumatic Stress Disorder and traumatic brain injuries and their families. ... of Veterans Affairs, programs with those of other departments and ...
... , , , ... state Department of Environmental Protection at schools in Beaver and Erie ... Environmental Protection Secretary John Hanger said today. , , ... USA Today that indicated potentially toxic air around the schools. , ...
... , SEATTLE, Sept. 17 National ... Helgen, Dr. Andrew Nicholson, and Mr. Sean Kosinski to its ... its offerings and responds to increasing demand for specialized technical ... , , "Integral is pleased to have ...
... , Alzheimer,s disease carries an ... toll that it takes on more than 5.3 million patients and ... 17 More than 5.3 million Americans are living with Alzheimer,s, ... 50 percent of people aged 85 and older have Alzheimer,s. According ...
Cached Medicine News:Health News:Write your Ticket to Madrid, Spain! 2Health News:Write your Ticket to Madrid, Spain! 3Health News:Time to Turn the Town Pink 2Health News:VA Secretary Helps Launch The Red Sox Foundation-Massachusetts General Hospital Home Base Program 2Health News:VA Secretary Helps Launch The Red Sox Foundation-Massachusetts General Hospital Home Base Program 3Health News:VA Secretary Helps Launch The Red Sox Foundation-Massachusetts General Hospital Home Base Program 4Health News:Results of Ongoing Testing Show Air Quality is Safe Near Schools in Beaver and Erie Counties in Pennsylvania 2Health News:Results of Ongoing Testing Show Air Quality is Safe Near Schools in Beaver and Erie Counties in Pennsylvania 3Health News:New Hires Signal Continued Expansion of Integral Consulting's Geochemistry, Hydrogeology, and Mining Capabilities 2Health News:World Alzheimer's Day: Leaders Call for Early Diagnosis + Aggressive Research 2
... Ergonomic Design for Unparalleled Comfort Pick one ... the balance. Notice the trigger and ejector positionsright ... because our pipettors are ergonomically designed to help ... of pipetting. Productivity In The Palm Of ...
... Ergonomic Design for Unparalleled Comfort Pick one ... the balance. Notice the trigger and ejector positionsright ... because our pipettors are ergonomically designed to help ... of pipetting. Productivity In The Palm Of ...
... ergonomic solution and best value in high ... action and ultra lightweight design reduce hand ... with long, lever tip ejector , Color ... universal tips or for greater performance use ...
... Finnpipette BioControl multichannel has ... as the single channel ... fits all seven multichannel ... tip cone modules. Both ...
Medicine Products: