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Proacta Incorporated and Yakult Honsha Announce an Agreement for the Collaborative Research, Development and Commercialization for Proacta's PR509 Compound
Date:2/22/2011

SAN DIEGO, Feb. 22, 2011 /PRNewswire/ -- Proacta Incorporated and Yakult Honsha Co., Ltd. (Tokyo: 2267) today announced the execution of a definitive agreement relating to the collaborative research, development and commercialization of Proacta's PR509, a hypoxia-activated pro-drug for the treatment of cancer.

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"We have worked diligently to arrive at this significant agreement with Yakult and we are very pleased to announce its execution," said John C. Gutheil, MD, Proacta's CEO. "This achievement underscores the commitment that our two companies have to a long-term, mutually rewarding relationship. It also exemplifies the ability of Proacta to leverage relationships with pharmaceutical partners to foster the likelihood of market success for its proprietary line of hypoxia-activated pro-drugs. We view this partnership with Yakult as further validation of the hypoxia-activated pro-drug platform and its potential as a novel therapeutic agent for patients suffering from cancer."

Mr. Shigeyoshi Sakamoto, Head, Pharmaceutical Division/ Managing Director, Member of the Board of Yakult, said, "We are delighted to have reached an agreement with Proacta regarding their PR509 for the research, development, and commercialization in Japan. The unique mechanism of action and well-developed preclinical data provide Yakult with the confidence necessary to join with Proacta in completing the preclinical and early clinical studies in the US in a collaborative manner. This collaboration should allow us to more quickly bring promising new treatments to patients suffering from cancer. We look forward to our work with Proacta through the collaborative research and development of PR509."

About PR509

PR509 is Proacta's proprietary hypoxia-activated irreversible multi-kinase inhibitor discovered at the Auckla
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SOURCE Proacta Incorporated
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