Navigation Links
Proacta Incorporated Announces IND Allowance for PR610

SAN DIEGO, Aug 29, 2012 /PRNewswire/ -- Proacta Incorporated announced today that the US Food and Drug Administration has allowed its Investigational New Drug (IND) Application for PR610, a hypoxia-activated, irreversible multi-kinase inhibitor (MKI) for the treatment of cancer.

The IND allowance permits Proacta to initiate human clinical trials of this novel, first in class treatment. Initially, development will focus on patients with non-small cell lung cancer who have developed resistance to reversible tyrosine kinase inhibitors such as erlotinib and /or gefitinib. In such cases, no effective treatment is currently available.

The first clinical study will be conducted at sites in the US and New Zealand. Proacta expects to initiate patient enrollment in the coming weeks.

About PR610

PR610 is Proacta's proprietary hypoxia-activated irreversible MKI discovered at the Auckland Cancer Society Research Centre, University of Auckland, New Zealand. Reversible MKI's are currently used for the treatment of several types of cancer. However, resistance often develops to reversible MKI's and side effects limit their use at higher doses.

PR610 utilizes an irreversible MKI that is activated in areas of severe hypoxia, a characteristic of most solid tumors. Localized release of the irreversible MKI within tumors leads to higher tumor concentrations and lower concentrations in normal tissues, which should result in improved efficacy and fewer side effects. In addition, irreversible MKI inhibitors are not affected by some of the resistance mechanisms that limit use of reversible MKI inhibitors.

In subsequent studies, Proacta expects to evaluate PR610 in other cancers that are currently treated with first-generation reversible tyrosine kinase inhibitors such as gastric, breast, and pancreatic.

In 2011, Proacta engaged in the collaboration for research, development and commercialization of PR610 in Japan with Yakult Honsha Co., Ltd. whose pharmaceutical business is focused on oncology.

About Proacta Incorporated

Proacta is a San Diego based biotechnology company dedicated to the development and commercialization of hypoxia-activated oncology drugs. Proacta has a pipeline of hypoxia-activated prodrugs for the treatment of cancer that are licensed from the University of Auckland in New Zealand. For more information, visit the Proacta web site at

SOURCE Proacta
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Accuray Incorporateds CEO to Speak at Morgan Stanley Global Healthcare Conference
2. ViroPharma Incorporated Reports Second Quarter 2012 Financial Results
3. Accuray Incorporated to Speak at Wells Fargo Healthcare Conference
4. Accuray Incorporated to Speak at Jefferies Global Healthcare Conference
5. Faruqi & Faruqi, LLP Announces Investigation of ViroPharma Incorporated
6. Insmed Incorporated Begins Screening Patients For TARGET-NTM U.S. Clinical Trial Of ARIKACE® In Patients With Non-tuberculous Mycobacterial Lung Disease
7. Insmed Incorporated Announces Lifting of Clinical Hold by U.S. Food and Drug Administration on ARIKACE® in Cystic Fibrosis Patients With Pseudomonas Lung Infections
8. The Law Firm of Levi & Korsinsky, LLP Announces Investigation into Possible Breaches of Fiduciary Duty by the Board of Gen-Probe Incorporated in Connection with the Sale of the Company to Hologic, Inc.
9. Tribogenics Announces Dual-Energy X-ray Source for XRF
10. Eaton Scientific Announces Clinical Trial Plans for Tropine 3 - Company to Seek FDA Approval as Novel Prescription Drug for Non-Hormonal Treatment of Hot Flashes in Menopausal Women
11. Cynosure Announces Upcoming Conference Presentations
Post Your Comments:
(Date:10/11/2017)... 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers ... an innovative way to use nonlinear optical imaging to ... new drugs. ... will show how researchers from BioPharmX and the Wellman ... used a suite of imaging techniques in what is ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, ... has amplified its effort during National Breast Cancer ... hereditary cancer risks. ... Clinical Oncology calculated that more than 10 million ... inherited mutations in BRCA1 or BRCA2 and have not ...
(Date:10/10/2017)... 2017  NDS received FDA 510(k) clearance in May 2017 for ... stand specifically designed for endoscopy environments. An innovative secondary monitor solution, ... solution to support the improvement of patient outcomes, procedural efficiency, and ... ... ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
Breaking Medicine News(10 mins):