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Privigen® Demonstrates Efficacy and Tolerability Among Patients With Various Immunodeficiencies, Data Show
Date:10/6/2010

ISTANBUL, Oct. 7 /PRNewswire/ -- Privigen®, the first and only 10% liquid intravenous immunoglobulin (IVIg) therapy stabilized with proline, is effective and well tolerated in patients with several primary and secondary immunodeficiencies, according to data presented today at the XIVth Meeting of the European Society for Immunodeficiencies. Results also demonstrate that Privigen offers significant protection against infection.

In a separate observational study, patients reported higher overall satisfaction with Privigen compared to previous treatments, along with fewer adverse events and improvements in quality of life. Even at higher rates of infusion, Privigen tolerability appeared superior to Sandoglobulin.

"Some patients have difficulty tolerating infusions at high rates, experiencing side effects such as general tiredness and long-lasting headaches," said Bodo Grimbacher, MD, Professor, Division of Immunology, Royal Free Hospital NHS Trust, London, and study investigator. "Our observation suggests that Privigen allows for higher infusion rates, substantially reducing the time needed for infusions."

Privigen is approved in the European Union, Switzerland, Canada and the United States for treating patients diagnosed with primary immune deficiency (PID) and immune thrombocytopenic purpura (ITP). In Europe, Privigen is also approved for treating Guillain-Barre Syndrome and Kawasaki-Syndrome.

Study DesignIn an interim analysis of an ongoing, multicenter, observational study to evaluate the efficacy and tolerability of Privigen, 76 patients received a total of 371 Privigen infusions. Overall, infection incidence decreased following initiation of treatment with Privigen compared with 6 months prior to the study (37 infections versus 160 infections). Patients who had not received any IVIg treatment for 6 months prior to study entry, and who received Privige
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SOURCE CSL Behring
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