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Prism Pharmaceuticals Receives FDA Approval of Ready-to-Use NEXTERONE® (amiodarone HCl) Premixed Injection
Date:11/18/2010

cular Tachycardia

Ventricular fibrillation is a condition in which the heart's electrical activity becomes disordered. When this happens, the heart's lower (pumping) chambers, called ventricles, contract in a rapid, unsynchronized way. (the ventricles "flutter" rather than beat). The heart pumps little or no blood. Ventricular fibrillation is very serious. Collapse and sudden cardiac death will follow in minutes unless medical help is provided immediately. 

Ventricular tachycardia is a fast or rapid heart rate that starts in the heart's lower chambers. Ventricular tachycardia may result from serious heart disease and usually requires prompt treatment.

Important Safety Information about NEXTERONE 

NEXTERONE is contraindicated in patients with: known hypersensitivity to any of the components of NEXTERONE, including iodine, or in patients with cardiogenic shock, marked sinus bradycardia, and second- or third-degree atrio-ventricular (AV) block unless a functioning pacemaker is available. If hypotension occurs, treat initially by slowing the infusion; additional standard therapy may be needed, including the following: vasopressor drugs, positive inotropic agents, and volume expansion. If bradycardia and AV block occur, treat by slowing the infusion rate or discontinuing NEXTERONE. The most common adverse reactions (1–2 percent) leading to discontinuation of intravenous amiodarone therapy are hypotension, asystole/cardiac arrest/pulseless electrical activity, ventricular tachycardia (VT), and cardiogenic shock. Other important adverse reactions are torsade de pointes (TdP), congestive heart failure, pulmonary disorders, and liver function test abnormalities.

For more information about NEXTERONE, including full prescribing information, visit www.prismpharma.com.

About Prism Pharmaceuticals, Inc.

Prism Pharmaceuticals, Inc., based in
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SOURCE Prism Pharmaceuticals, Inc.
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