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Donald Fuller, M.D., a radiation oncologist from Genesis Healthcare in San Diego, presented findings from a multi-center study of 260 patients with low and intermediate-risk prostate cancer treated using CyberKnife SBRT at 17 institutions, using an approach that emulates the dosimetry of high dose rate (HDR) brachytherapy.
Patients were followed for up to 48 months with a median follow-up of 24 months, and found to have disease-free survival of 98.5 percent, as updated during his presentation. Urinary and rectal toxicities reported at a minimum 1 year follow-up were in line with outcomes of traditional radiation therapy and erectile function returned to baseline by 3 years, with minimal disruption after treatment.
"These findings should encourage men to explore CyberKnife SBRT as a viable alternative to surgery or other radiation treatments, such as brachytherapy and intensity-modulated radiation therapy," said Dr. Fuller. "Findings to date indicate we may be able to minimize the undesirable side effects typically associated with other treatment modalities and help to preserve patients' quality of life during and after prostate cancer treatment."
Additionally, seven posters highlighting CyberKnife prostate SBRT experience were presented by researchers from the University of California San Francisco, Georgetown University Hospital, and Winthrop University Hospital, as well as additional research from Flushing Radiation Oncology and Swedish Cancer Institute in Seattle, further supporting the maturing body of prostate SBRT evidence.
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