Navigation Links
Prescription Sleeping Pill Use Tied to Cancer
Date:8/18/2008

SAN DIEGO, Aug. 18 /PRNewswire/ -- The next time you consider popping a pill when you have trouble nodding off, it might be worth counting sheep instead. A senior psychiatrist at the Scripps Clinic Sleep Center in San Diego, Calif. has found evidence that taking sleeping pills regularly can increase the risk of skin cancer.

Daniel F. Kripke, M.D.'s article, based on a compilation of studies involving sleeping pills and cancer, has just been published in the Journal of Sleep Research. It appears with an editorial authored by Dr. Gary D. Friedman, an epidemiologist at Stanford University's School of Medicine and adjunct investigator at the Kaiser Permanente Medical Care Program who has vast experience in investigating the carcinogenic effects of drugs.

The effects of 556 person-years of taking either zaleplon (Sonata), Eszopiclone (Lunesta), ramelteon (Rozerem) and zolpidem (Ambien) were assessed, compared to a control group who took a placebo over 230 person-years. Kripke found eight non-melanoma skin cancers and four tumors of uncertain malignancy in the groups that took sleeping pills compared to none in the placebo groups.

Lab animals given high doses of hypnotic drugs are known to have developed kidney, thyroid and testicular cancers and suffer chromosome damage, which is a sign of carcinogenicity. Although a direct causal link between cancer and sleeping pills has still not been proven, Kripke urges additional studies as well as serious epidemiological investigations, given the fact that sleeping pill use is constantly rising and three new types have been put on the market in addition to Ambien (zolpidem), the most popular brand used in the United States.

"Because the compilation mixes diverse studies of several drugs and the number of cancers observed during controlled hypnotics trials remains small," Kripke writes, "this preliminary analysis should be viewed as an investigative step, rather than sufficient proof that modern hypnotics cause cancer."

But both he and Friedman -- who congratulated Kripke for raising this important issue even though the reviewer remained somewhat skeptical of a causal link -- urge caution and suggest that regulatory bodies and the U.S. National Institutes of Health keep an eye on cancer cases reported by sleeping pill users.

The Journal of Sleep Research is published by Wiley-Blackwell and can be accessed online at http://www.blackwellpublishing.com/jsr

ABOUT SCRIPPS CLINIC

Founded in 1924, Scripps Clinic is a multi-specialty, outpatient care facility caring for patients at multiple locations throughout San Diego County including Torrey Pines, Del Mar, Encinitas, La Jolla, Mission Valley, Rancho Bernardo, Rancho San Diego and Santee. Scripps Clinic and its physicians are world-renown for research-driven care and medical specialty expertise and is an operating unit of Scripps Health, a not-for-profit, community-based health care delivery network that includes more than 2,600 affiliated physicians, five acute-care hospitals, home health care and associated support services. Scripps Health is one of the largest health care organizations in San Diego County, drawing from the expertise of more than 10,000 health care professionals.

HIGHLIGHTS:

A researcher at Scripps Clinic has published an article in the Journal of Sleep Research indicating that people who use popular prescription sleeping pills are more likely to develop cancer than those who do not use sleeping pills.

AVAILABLE FOR INTERVIEWS:

-- Daniel Kripke, M.D., study author, Co-Director for Research, Scripps Clinic Sleep Center


'/>"/>
SOURCE Scripps Clinic
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Lack of Medicare Part D Coverage for All Medically Necessary Prescriptions Endangers Older Americans and Those with Chronic Diseases and Disabilities
2. US FDA Grants Orphan Drug Status to Immtechs Pafuramidine for Treatment of African Sleeping Sickness
3. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
4. Immtech Receives $5.1 Million to Further African Sleeping Sickness Clinical Trials
5. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. Indevus Receives Approvable Letter From FDA for VALSTAR(R) for Bladder Cancer Therapy
8. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
9. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
10. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
11. Novel Technology Breaks Through Cancer Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/4/2016)... , Feb. 4, 2016 In response to the ... FDA,s Deputy Commissioner for Medical Products and Tobacco, along with ... reassess the agency,s approach to opioid medications. The plan will ... providing patients in pain access to effective relief. ... , Re-examine the risk-benefit paradigm for opioids and ...
(Date:2/4/2016)...  Blueprint Medicines Corporation (NASDAQ: BPMC ), ... investigational kinase medicines for patients with genomically defined ... of directors of Lonnel Coats , a ... industry-related experience. Jeffrey Albers , ... strategic experience developing and commercializing numerous oncology products ...
(Date:2/4/2016)... SIOUX FALLS, S.D. , Feb. 4, 2016 ... patient and guest technology solutions, today announced that ... SONIFI Health Senior Living Engagement System. The system ... information tool that residents access through a tablet ... --> The resident engagement system provides access ...
Breaking Medicine Technology:
(Date:2/7/2016)... Orion, Clarkston, Metamora, Michigan (PRWEB) , ... February 07, 2016 , ... ... Friday in recognition of National Wear Red Day. National Wear Red Day is ... and stroke in women. Heart disease and stroke cause 1 in 3 deaths among ...
(Date:2/6/2016)... ... February 06, 2016 , ... ... ADVISORY: 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , ... the world with an estimated 5000 perioperative nurses in attendance to study ...
(Date:2/6/2016)... ... February 06, 2016 , ... Shark Finds and Kevin ... of a new DRTV campaign with Belly Bands. , Having a dog is great—except ... to puppy pads and find nothing works, get Belly Bands, the easiest way ...
(Date:2/5/2016)... ... 05, 2016 , ... Love is in the air at King Kullen! The ... and packaging. This staple for Valentine’s Day is a must-have, and can be picked ... Day, not only are long-stem roses available, but also other flower bouquets, elegantly wrapped ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... setting the stage for new clinical and scientific initiatives have all marked the ... she was appointed President and CEO of the nation’s oldest cancer center, Candace ...
Breaking Medicine News(10 mins):