Navigation Links
Preliminary Phase 2 Data of Ocera Therapeutics' OCR-002 for the Treatment of Liver Cirrhosis and Upper GI Bleeding Show Potent Ammonia Reduction
Date:5/29/2012

patients with liver cirrhosis (n=10) shows that OCR-002 is well tolerated up to 10g/24h and provides a significant, rapid and durable ammonia reduction to normal levels after 36 hours of treatment.  All patients tolerated study drug well for 5 days. There were no severe toxicities associated with the treatment and no incidence of HE, with patients doing well at the 30 day follow up. A rapid drop in ammonia from 80.01+/-13.44 uM at baseline to 41.95+/-4.99 uM was observed at 36 hours (ANOVA, p<0.05).

The Phase 2 clinical trial is ongoing and will enroll 48 patients with cirrhosis of the liver. The first part of the trial recently completed was an open-label study to confirm the safety and tolerability of OCR-002 seen in earlier clinical trials. The second phase is a double-blind, placebo-controlled study and will measure as the primary endpoint ammonia plasma concentration and improvement in HE as a secondary endpoint.

OCR-002, developed by Ocera Therapeutics, has received Orphan Drug designation in the U.S. and Europe and has fast track status in the U.S. OCR-002 is also being evaluated as a treatment of acute liver failure in the U.S. It is estimated that there are up to 1 million cirrhotic patients in the U.S., of which 150,000-200,000 patients are hospitalized due to complications of encephalopathy costing the healthcare system over $1.2 billion every year.

About OCR-002
Ocera in-licensed OCR-002 (ornithine phenylacetate), an ammonia scavenger designed to rapidly lower systemic hyperammonemia and treat hepatic encephalopathy (HE) in patients with liver cirrhosis and acute liver failure from University College of London. OCR-002, through its novel mechanism of action, directly lowers circulating blood levels of ammonia by enabling alternate metabolic pathways in the muscle and kidney in patients with liver failure and is patent protected until 2031. OCR-002 is being developed as an injectable for hospitaliz
'/>"/>

SOURCE Ocera Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Ampio Announces Positive Preliminary Update on the Optina™ Clinical Trial to Treat Diabetic Macular Edema and Decision to Conclude the Study Ahead of Schedule
2. Cardinal Health Statement in Response to Preliminary Injunction Hearing February 29, 2012
3. Vermillion to Report Preliminary Results for Fourth Quarter and Fiscal Year 2011 on February 23, 2012
4. Watson Confirms Court Stays Preliminary Injunction
5. Watson Announces Preliminary 2011 Non-GAAP Earnings of $4.75-$4.77
6. Hill-Rom Announces Preliminary Fiscal First Quarter Financial Results; Updates 2012 Financial Outlook
7. Volcano Corporation Announces Preliminary Fourth Quarter 2011 Revenues
8. CareFusion Announces Preliminary Second Quarter Results
9. Sanofi Announces Court Ruling Granting Preliminary Injunction Against Synvisc-One® Competitor Product
10. InterMune Reports Preliminary Fourth Quarter 2011 Esbriet® (pirfenidone) Revenue and Other Recent Business Highlights
11. PDL BioPharma Announces Expiration and Preliminary Results of its Exchange Offer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... , Oct. 22, 2014  Cephasonics, a technology-innovation ... introduction of the cQUB™-1 (cQuest Ultrasound Box™-1), the first ... systems designed and manufactured by Cephasonics for purchase by ... model number. Cephasonics will be showcasing the cQUB-1 for ... this week in Chongqing, China ...
(Date:10/22/2014)... -- Antigen Discovery Inc. (ADi), a privately held company ... receipt of a National Institutes of Health (NIH) Phase ... of Dental and Craniofacial Research (NIDCR). The one-year $225,000 ... Microarray Chip, which will contain every protein in all ... the development of safe and effective vaccines and therapies ...
(Date:10/22/2014)... Oct. 22, 2014  Paper Pak Industries, a ... APLS ® Body Guard Bio, a disposable, ... of bacteria and virus while protecting service providers ... Bio features a rugged, external nylon shell, watertight ... a leak-proof inner chamber that contains contaminated and ...
Breaking Medicine Technology:Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2
... of three U.S. adults plan to skip their flu shot ... Against that backdrop, two top clinical leaders in long-term acute ... influenza season can be a deadly time for those suffering ... (Chronic Obstructive Pulmonary Disease). Such patients need to take extra ...
... Oct. 26, 2011 The Preserve ... a call to action to protect hard-working Americans from ... by stopping the planned merger between Express Scripts Inc. ... (PBM) companies. The call to action, posted on the ...
Cached Medicine Technology:Poll: One Out of Three U.S. Adults Not Planning to Get Flu Shot This Year 2Nationwide Coalition Issues 'Call To Action' To Stop Express Scripts/Medco Merger 2
(Date:10/22/2014)... 2014 (HealthDay News) -- Measures taken by Firestone officials ... Liberia may have limited the spread of the disease ... The Firestone Natural Rubber Co. provides health services to ... nearby densely populated communities. Between Aug. 1 and ... cases among those 80,000 people. That incidence rate of ...
(Date:10/22/2014)... By Dennis Thompson HealthDay ... freelance cameraman who was diagnosed with Ebola while working for ... system and can leave the special isolation unit at Nebraska Medical ... two weeks, the hospital said Tuesday. A blood test confirmed ... Ashoka Mukpo, 33, can head home to Providence, R.I., NBC ...
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
(Date:10/20/2014)... The Advocator Group, LLC is ... Foundation for Suicide Prevention’s (AFSP) Out of the Darkness ... organization that hosts hundreds of community walks throughout the ... used to help understand and prevent suicide through not ... well. , The Advocator Group shares this passion ...
(Date:10/20/2014)... 20, 2014 Women’s health specialist, Dr. ... & Gynecology of Columbus, Inc., A Division of MaternOhio ... to more than 100,000 patients annually. Dr. Murphy will ... and stages of a women’s life. She is accepting ... in Westerville and Dublin. , Dr. Murphy offers a ...
Breaking Medicine News(10 mins):Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3
... examines a cluster of 15 murders and attempted homicides ... Colorado,Ft. Carson Killings: The New Casualties of War, ... ETDALLAS, May 28 HDNet World Report , ... about a string of 15 murders and attempted homicides ...
... WASHINGTON, May 28 A new statewide poll ... Congress passing a bill to give the U.S. Food and ... The U.S. Senate is expected to debate this issue next ... role in determining whether Congress will finally pass this life-saving ...
... BOSTON, Mass. (May 28, 2009) Corrupt lifestyles and vices go ... miscreant needs customary societal amenities to get by. It,s the same ... of genetic mutations to wreak havoc, they must sustain their activity, ... a new study in the May 29 issue of Cell ...
... and AIDS in Catalonia (CEEISCAT) started a pioneering study ... of sexually-transmitted diseases (STDs) among female sex workers (SWs). ... with both HIV and other diseases over time, as ... "The phenomenon of prostitution has changed over recent years ...
... in ensuring safe patient use of opioid medications lies ... and dispensing medications may fail to protect patients from ... be accomplished by conducting a failure mode and effects ... systems for preventing medication errors, told a public meeting ...
... poll of registered voters finds that 62 percent of voters ... and Drug Administration (FDA) the authority to regulate tobacco products. ... next week, and Senators Cochran and Wicker will play a ... life-saving legislation.(Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ) , ...
Cached Medicine News:Health News:HDNet World Report Investigates an Alarming String of Murders Committed by Iraq War Veterans 2Health News:HDNet World Report Investigates an Alarming String of Murders Committed by Iraq War Veterans 3Health News:HDNet World Report Investigates an Alarming String of Murders Committed by Iraq War Veterans 4Health News:New Virginia Poll: 71 Percent of Voters Strongly Support FDA Regulation of Tobacco Products 2Health News:New Virginia Poll: 71 Percent of Voters Strongly Support FDA Regulation of Tobacco Products 3Health News:Cancer cells need normal, nonmutated genes to survive 2Health News:Spanish prostitutes least likely to use condoms 2Health News:Process for Planning Safe Pain Treatment Outlined in Presentation at FDA Meeting 2Health News:New Mississippi Poll: Voters Strongly Support FDA Regulation of Tobacco Products 2Health News:New Mississippi Poll: Voters Strongly Support FDA Regulation of Tobacco Products 3
... order products are offered as 1-piece or ... The modular instruments may be customized with ... as ratchets, insulation and flush ports. Many ... Customer specifications may affect delivery times. ...
... Many special order products are offered as ... long lengths. The modular instruments may be ... options such as ratchets, insulation and flush ... Mediflex stock. Customer specifications may affect delivery ...
... Many special order products are offered as ... long lengths. The modular instruments may be ... options such as ratchets, insulation and flush ... Mediflex stock. Customer specifications may affect delivery ...
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
Medicine Products: